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学科主题: 临床医学
题名:
Upper cervical spine chordoma of C2-C3
作者: Jiang, Liang; Liu, Zhong Jun; Liu, Xiao Guang; Ma, Qing Jun; Wei, Feng; Lv, Yang; Dang, Geng Ting
关键词: Chordoma ; Atlantoaxial spine ; Surgery
刊名: EUROPEAN SPINE JOURNAL
发表日期: 2009-03-01
DOI: 10.1007/s00586-009-0907-y
卷: 18, 期:3, 页:293-300
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Orthopedics
研究领域[WOS]: Neurosciences & Neurology ; Orthopedics
关键词[WOS]: EN-BLOC RESECTION ; MOBILE SPINE ; SURGICAL TECHNIQUE ; RADIATION-THERAPY ; SKULL BASE ; SPONDYLECTOMY ; EXCISION
英文摘要:

Chordoma is a rare low-grade malignant neoplasm derived from the remnants of the embryonic notochord. This locally invasive neoplasm is subject to recurrence after treatment. The median survival time is estimated to be 6.3 years. Various treatment approaches have been attempted, including radical excision, radiotherapy and chemotherapy. Treatment outcome is significantly influenced by the size and site of the chordoma. Recently, Imatinib, a molecular-targeted agent, has been shown to have antitumor activity in chordoma. Proton radiotherapy, stereotactic radiotherapy and intensity-modulated radiotherapy have also been used. Surgical treatment is still the primary choice for chordoma. It has become more aggressive in recent years, evolving from intralesional or partial excision to en bloc resection. However, upper cervical localizations make such en bloc resection in most cases not possible. We present and discuss the therapeutic challenges of a young female with large retropharyngeal chordoma who presented to our institution after conventional photon beam radiotherapy. This C2/3 tumor was classified IB according to the Enneking classification. It distributed to layers A-D and sectors 1-6 according to the Weinstein Boriani Biagini Classification. The left vertebral artery (VA) was encapsulated and displaced. One stage intralesional extracapsular tumor excision and reconstruction was achieved by combined bilateral high anterior cervical approaches and posterior approach. No recurrence or metastasis was observed 3 years after the operation. She returned to her previous occupation as office worker.

语种: 英语
WOS记录号: WOS:000263870200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55816
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: Peking Univ, Dept Orthopaed, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Liang,Liu, Zhong Jun,Liu, Xiao Guang,et al. Upper cervical spine chordoma of C2-C3[J]. EUROPEAN SPINE JOURNAL,2009,18(3):293-300.
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