IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Incidental Prostate Cancer in Asian Men: High Prevalence of Incidental Prostatic Adenocarcinoma in Chinese Patients Undergoing Radical Cystoprostatectomy for Treatment of Bladder Cancer and Selection of Candidates for Prostate-Sparing Cystectomy
Yang, Xinyu1; Monn, M. Francesca2; Liu, Libo1; Liu, Yuli1; Su, Jinwei1; Lyu, Tianjing1; Gong, Yanqing1; Wang, Lisha3; Davidson, Darrell D.4; Cheng, Liang2,4
关键词Prostate Incidental Prostate Cancer Cystoprostatectomy Clinically Insignificant Bladder Cancer Asian Chinese Men
刊名PROSTATE
2015-06-01
DOI10.1002/pros.22966
75期:8页:845-854
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]TRANSITIONAL-CELL CARCINOMA ; CLINICOPATHOLOGICAL FEATURES ; UROTHELIAL CARCINOMA ; PREDICTIVE FACTORS ; ANTIGEN LEVEL ; KOREAN MEN ; SPECIMENS ; INVOLVEMENT ; RISK ; EXPERIENCE
英文摘要

BackgroundPrevious studies report a low prevalence of incidental prostate cancer in Chinese patients (3-7%). We evaluated incidental prostatic adenocarcinoma (PCa) and urothelial carcinoma (UCa) involvement of the prostate in cystoprostatectomy specimens.

MethodsWe analyzed 340 cystoprostatectomy specimens from patients who underwent radical cystoprostatectomy for the treatment of bladder cancer in China from 2004 to 2014. None of the patients had known prostate cancer prior to cystoprostatectomy.

ResultsOverall, 180 (53%) patients had either PCa or UCa in the prostate. We found that 95 (28%) had PCa and 115 (34%) had UCa involvement of prostate. The rate of incidental prostate cancer was 21% and 31%, respectively, from two study periods (2004-2008 and 2009-2014). Among the 95 patients with PCa, 19 (20%) had Gleason score of 7, nine (10%) had PCa tumor volume >0.5cc, and eight (8.4%) had extracapsular extension. Of the 115 with prostatic UCa, 61 had prostatic urethra and/or periurethral prostatic duct involvement only, while 54 had prostatic stromal invasion. Age (odds ratio [OR]=1.04, P=0.001), increasing stage of bladder tumor (OR=1.28, P=0.005), multifocal tumors of bladder (OR=3.22, P<0.001), carcinoma in situ (CIS) in the bladder (OR=5.52, P<0.001), and bladder neck involvement (OR=6.12, P<0.001) were strongly associated with prostatic UCa.

ConclusionsThe rate of incidental PCa in cystoprostatectomy specimens in China has increased over the last decade. Patients with advanced age, elevated serum PSA level, advanced bladder tumor stage, multifocal bladder tumors, CIS in the bladder, and tumor location at the bladder neck should be excluded as candidates for prostate-sparing cystectomy. Prostate 75:845-854, 2015. (c) 2015 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000353235500007
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55822
专题北京大学第一临床医学院_泌尿外科
作者单位1.Peking Univ, Inst Urol, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Indiana Univ Sch Med, Dept Urol, Indianapolis, IN 46202 USA
3.Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai 200433, Peoples R China
4.Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA
推荐引用方式
GB/T 7714
Yang, Xinyu,Monn, M. Francesca,Liu, Libo,et al. Incidental Prostate Cancer in Asian Men: High Prevalence of Incidental Prostatic Adenocarcinoma in Chinese Patients Undergoing Radical Cystoprostatectomy for Treatment of Bladder Cancer and Selection of Candidates for Prostate-Sparing Cystectomy[J]. PROSTATE,2015,75(8):845-854.
APA Yang, Xinyu.,Monn, M. Francesca.,Liu, Libo.,Liu, Yuli.,Su, Jinwei.,...&Cheng, Liang.(2015).Incidental Prostate Cancer in Asian Men: High Prevalence of Incidental Prostatic Adenocarcinoma in Chinese Patients Undergoing Radical Cystoprostatectomy for Treatment of Bladder Cancer and Selection of Candidates for Prostate-Sparing Cystectomy.PROSTATE,75(8),845-854.
MLA Yang, Xinyu,et al."Incidental Prostate Cancer in Asian Men: High Prevalence of Incidental Prostatic Adenocarcinoma in Chinese Patients Undergoing Radical Cystoprostatectomy for Treatment of Bladder Cancer and Selection of Candidates for Prostate-Sparing Cystectomy".PROSTATE 75.8(2015):845-854.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Xinyu]的文章
[Monn, M. Francesca]的文章
[Liu, Libo]的文章
百度学术
百度学术中相似的文章
[Yang, Xinyu]的文章
[Monn, M. Francesca]的文章
[Liu, Libo]的文章
必应学术
必应学术中相似的文章
[Yang, Xinyu]的文章
[Monn, M. Francesca]的文章
[Liu, Libo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。