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学科主题: 临床医学
题名:
Incidental Prostate Cancer in Asian Men: High Prevalence of Incidental Prostatic Adenocarcinoma in Chinese Patients Undergoing Radical Cystoprostatectomy for Treatment of Bladder Cancer and Selection of Candidates for Prostate-Sparing Cystectomy
作者: Yang, Xinyu1; Monn, M. Francesca2; Liu, Libo1; Liu, Yuli1; Su, Jinwei1; Lyu, Tianjing1; Gong, Yanqing1; Wang, Lisha3; Davidson, Darrell D.4; Cheng, Liang2,4
关键词: prostate ; incidental prostate cancer ; cystoprostatectomy ; clinically insignificant ; bladder cancer ; Asian Chinese men
刊名: PROSTATE
发表日期: 2015-06-01
DOI: 10.1002/pros.22966
卷: 75, 期:8, 页:845-854
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: TRANSITIONAL-CELL CARCINOMA ; CLINICOPATHOLOGICAL FEATURES ; UROTHELIAL CARCINOMA ; PREDICTIVE FACTORS ; ANTIGEN LEVEL ; KOREAN MEN ; SPECIMENS ; INVOLVEMENT ; RISK ; EXPERIENCE
英文摘要:

BackgroundPrevious studies report a low prevalence of incidental prostate cancer in Chinese patients (3-7%). We evaluated incidental prostatic adenocarcinoma (PCa) and urothelial carcinoma (UCa) involvement of the prostate in cystoprostatectomy specimens.

MethodsWe analyzed 340 cystoprostatectomy specimens from patients who underwent radical cystoprostatectomy for the treatment of bladder cancer in China from 2004 to 2014. None of the patients had known prostate cancer prior to cystoprostatectomy.

ResultsOverall, 180 (53%) patients had either PCa or UCa in the prostate. We found that 95 (28%) had PCa and 115 (34%) had UCa involvement of prostate. The rate of incidental prostate cancer was 21% and 31%, respectively, from two study periods (2004-2008 and 2009-2014). Among the 95 patients with PCa, 19 (20%) had Gleason score of 7, nine (10%) had PCa tumor volume >0.5cc, and eight (8.4%) had extracapsular extension. Of the 115 with prostatic UCa, 61 had prostatic urethra and/or periurethral prostatic duct involvement only, while 54 had prostatic stromal invasion. Age (odds ratio [OR]=1.04, P=0.001), increasing stage of bladder tumor (OR=1.28, P=0.005), multifocal tumors of bladder (OR=3.22, P<0.001), carcinoma in situ (CIS) in the bladder (OR=5.52, P<0.001), and bladder neck involvement (OR=6.12, P<0.001) were strongly associated with prostatic UCa.

ConclusionsThe rate of incidental PCa in cystoprostatectomy specimens in China has increased over the last decade. Patients with advanced age, elevated serum PSA level, advanced bladder tumor stage, multifocal bladder tumors, CIS in the bladder, and tumor location at the bladder neck should be excluded as candidates for prostate-sparing cystectomy. Prostate 75:845-854, 2015. (c) 2015 Wiley Periodicals, Inc.

语种: 英语
WOS记录号: WOS:000353235500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55822
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Inst Urol, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Indiana Univ Sch Med, Dept Urol, Indianapolis, IN 46202 USA
3.Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai 200433, Peoples R China
4.Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA

Recommended Citation:
Yang, Xinyu,Monn, M. Francesca,Liu, Libo,et al. Incidental Prostate Cancer in Asian Men: High Prevalence of Incidental Prostatic Adenocarcinoma in Chinese Patients Undergoing Radical Cystoprostatectomy for Treatment of Bladder Cancer and Selection of Candidates for Prostate-Sparing Cystectomy[J]. PROSTATE,2015,75(8):845-854.
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