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Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension
Zhang, Shaodan1,2; Li, Weiyi1; Wang, Wenqian1; Zhang, Samuel S.3,4; Huang, Ping1; Zhang, Chun1
刊名PLOS ONE
2013-01-31
DOI10.1371/journal.pone.0055683
8期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Chinese State Natural and Science ; Chinese State Natural and Science
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RETINAL GANGLION-CELLS ; FIBRILLARY ACIDIC PROTEIN ; FOCAL CEREBRAL-ISCHEMIA ; SPINAL-CORD-INJURY ; REACTIVE ASTROCYTES ; RECEPTOR ACTIVATION ; PROMOTES SURVIVAL ; OXIDATIVE STRESS ; JAK/STAT PATHWAY ; GENE-EXPRESSION
英文摘要

Lamina cribosa, an astrocyte-rich region, is the origin of axonal degeneration in glaucomatous neuropathy. Astrocytes are particularly activated during optic nerve (ON) degeneration and are likely to contribute to the pathogenesis of glaucomatous optic neuropathy. Signalling mechanisms that regulate different aspects of astrocyte reactiviation in response to intraocular hypertensive injury are not well defined. Signal transducer and activator of transcription protein-3 (STAT3) is a transcription factor that participates in many biological processes and has been implicated as activator of reactive astrogliosis. In this study, we investigated the role of STAT3 in regulating the activation of astrocytes to transient intraocular hypertension in vivo by using a rat ocular hypertension model. ON astrocytes hypertrophy was observed early after intraocular hypertensive stress. Morphological changes in glial fibrillary acidic protein (GFAP) positive cells coupled with axon loss in the optic nerve was detected at day 7 after the injury. Nestin was significantly upregulated in ON astrocytes as early as day 2 post injury and kept elevated through post injury day 7. Phosphorylated STAT3 (pSTAT3) was markedly upregulated in ON astrocytes at post injury day 1, prior to the reactivation of ON astrocytes. These findings indicate that STAT3 signalling is involved in the initiation of astrocyte reactivation in optic nerve injury.

语种英语
所属项目编号30772376 ; 81041008
资助者Chinese State Natural and Science ; Chinese State Natural and Science
WOS记录号WOS:000314610600145
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55831
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Ctr Eye, Hosp 3, Dept Ophthalmol, Beijing 100871, Peoples R China
2.4th Peoples Hosp Shenyang, Dept Ophthalmol, Shenyang Inst Ophthalmol, Liaoning, Peoples R China
3.Penn State Univ, Dept Neural & Behav Sci, Hershey, PA USA
4.Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore
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GB/T 7714
Zhang, Shaodan,Li, Weiyi,Wang, Wenqian,et al. Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension[J]. PLOS ONE,2013,8(1).
APA Zhang, Shaodan,Li, Weiyi,Wang, Wenqian,Zhang, Samuel S.,Huang, Ping,&Zhang, Chun.(2013).Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension.PLOS ONE,8(1).
MLA Zhang, Shaodan,et al."Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension".PLOS ONE 8.1(2013).
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