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学科主题: 口腔医学
题名:
Hierarchical Intrafibrillar Nanocarbonated Apatite Assembly Improves the Nanomechanics and Cytocompatibility of Mineralized Collagen
作者: Liu, Yan1; Luo, Dan2,3; Kou, Xiao-Xing1; Wang, Xue-Dong1; Tay, Franklin R.4; Sha, Yin-Lin2,3; Gan, Ye-Hua5; Zhou, Yan-Heng1
关键词: hierarchy ; intrafibrillar nanocarbonated apatite ; collagen ; nanomechanics ; cytocompatibility
刊名: ADVANCED FUNCTIONAL MATERIALS
发表日期: 2013-03-20
DOI: 10.1002/adfm.201201611
卷: 23, 期:11, 页:1404-1411
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: CALCIUM-PHOSPHATE ; MATRIX PROTEIN ; IN-VITRO ; BONE ; FIBRILS ; NUCLEATION ; MICROSCOPY ; CRYSTALS ; HYDROXYAPATITE ; NANOSCALE
英文摘要:

Nanoscale replication of the hierarchical organization of minerals in biogenic mineralized tissues is believed to contribute to the better mechanical properties of biomimetic collagen scaffolds. Here, an intrafibrillar nanocarbonated apatite assembly is reported, which has a bone-like hierarchy, and which improves the mechanical and biological properties of the collagen matrix derived from fibril-apatite aggregates. A modified biomimetic approach is used, which based on the combination of poly(acrylic acid) as sequestration and sodium tripolyphosphate as templating matrix-protein analogs. With this modified dual-analog-based biomimetic approach, the hierarchical association between collagen and the mineral phase is discerned at the molecular and nanoscale levels during the process of intrafibrillar collagen mineralization. It is demonstrated by nanomechanical testing, that intrafibrillarly mineralized collagen features a significantly increased Young′s modulus of 13.7 +/- 2.6 GPa, compared with pure collagen (2.2 +/- 1.7 GPa) and extrafibrillarly-mineralized collagen (7.1 +/- 1.9 GPa). Furthermore, the hierarchy of the nanocarbonated apatite assembly within the collagen fibril is critical to the collagen matrix′s ability to confer key biological properties, specifically cell proliferation, differentiation, focal adhesion, and cytoskeletal arrangement. The availability of the mineralized collagen matrix with improved nanomechanics and cytocompatibility may eventually result in novel biomaterials for bone grafting and tissue-engineering applications.

语种: 英语
所属项目编号: 2010DFB32980 ; 30973360 ; 81201198
项目资助者: Projects of International Cooperation and Exchanges ; National Science Foundations of China ; Peking-Tsinghua Center for Life Sciences
WOS记录号: WOS:000316261400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55832
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ, Biomed Ctr X, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China
4.Georgia Hlth Sci Univ, Dept Endodont, Augusta, GA 30912 USA
5.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Liu, Yan,Luo, Dan,Kou, Xiao-Xing,et al. Hierarchical Intrafibrillar Nanocarbonated Apatite Assembly Improves the Nanomechanics and Cytocompatibility of Mineralized Collagen[J]. ADVANCED FUNCTIONAL MATERIALS,2013,23(11):1404-1411.
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