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学科主题: 口腔医学
题名:
The prognostic value of glycerol-3-phosphate dehydrogenase 1-like expression in head and neck squamous cell carcinoma
作者: Feng, Zhien; Li, Jian Nan; Wang, Lin; Pu, Yin Fei; Wang, Yixiang; Guo, Chuan Bin
关键词: biomarker ; glycerol-3-phosphate dehydrogenase 1-like ; head and neck ; prognosis ; squamous cell carcinoma
刊名: HISTOPATHOLOGY
发表日期: 2014-02-01
DOI: 10.1111/his.12258
卷: 64, 期:3, 页:348-355
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: CANCER
英文摘要:

AimsIn this study, we sought to determine the prognostic significance of glycerol-3-phosphate dehydrogenase 1-like (GPD1L) expression in head and neck squamous cell carcinoma (HNSCC).

Methods and resultsThe mRNA levels of GPD1L were measured in 70 paired HNSCC and corresponding adjacent normal tissues using real-time PCR. GPD1L protein levels were evaluated in HNSCC from 135 patients using immunohistochemical staining. Correlations were analysed between GPD1L levels and local recurrence rate, regional recurrence rate, second primary malignancy rate), disease-free survival (DFS) and disease-specific survival (DSS). The results of real-time PCR showed that, compared with the paired normal tissues, mRNA levels of GPD1L were decreased significantly in HNSCC (P<0.001). Patients whose tumours showed high GPD1L protein expression had a significantly better prognosis than those whose tumours showed low expression (61.3% versus 21.4%, P<0.001 for DFS; 68% versus 39.3%, P=0.001 for DSS). High GPD1L expression was associated with a lower local recurrence rate than low GPD1L expression (P=0.049). Multivariate survival analysis also showed that GPD1L expression was an independent prognostic factor (P=0.001).

ConclusionsOur results indicate that the GPD1L expression is a strong predictor for local recurrence and survival in HNSCC.

语种: 英语
所属项目编号: 2009AA045201 ; 81302350 ; 2013M530495
项目资助者: National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号: WOS:000330638700003
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55833
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Feng, Zhien,Li, Jian Nan,Wang, Lin,et al. The prognostic value of glycerol-3-phosphate dehydrogenase 1-like expression in head and neck squamous cell carcinoma[J]. HISTOPATHOLOGY,2014,64(3):348-355.
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