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The prognostic value of glycerol-3-phosphate dehydrogenase 1-like expression in head and neck squamous cell carcinoma
Feng, Zhien; Li, Jian Nan; Wang, Lin; Pu, Yin Fei; Wang, Yixiang; Guo, Chuan Bin
关键词Biomarker Glycerol-3-phosphate Dehydrogenase 1-like Head And Neck Prognosis Squamous Cell Carcinoma
刊名HISTOPATHOLOGY
2014-02-01
DOI10.1111/his.12258
64期:3页:348-355
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]CANCER
英文摘要

AimsIn this study, we sought to determine the prognostic significance of glycerol-3-phosphate dehydrogenase 1-like (GPD1L) expression in head and neck squamous cell carcinoma (HNSCC).

Methods and resultsThe mRNA levels of GPD1L were measured in 70 paired HNSCC and corresponding adjacent normal tissues using real-time PCR. GPD1L protein levels were evaluated in HNSCC from 135 patients using immunohistochemical staining. Correlations were analysed between GPD1L levels and local recurrence rate, regional recurrence rate, second primary malignancy rate), disease-free survival (DFS) and disease-specific survival (DSS). The results of real-time PCR showed that, compared with the paired normal tissues, mRNA levels of GPD1L were decreased significantly in HNSCC (P<0.001). Patients whose tumours showed high GPD1L protein expression had a significantly better prognosis than those whose tumours showed low expression (61.3% versus 21.4%, P<0.001 for DFS; 68% versus 39.3%, P=0.001 for DSS). High GPD1L expression was associated with a lower local recurrence rate than low GPD1L expression (P=0.049). Multivariate survival analysis also showed that GPD1L expression was an independent prognostic factor (P=0.001).

ConclusionsOur results indicate that the GPD1L expression is a strong predictor for local recurrence and survival in HNSCC.

语种英语
WOS记录号WOS:000330638700003
项目编号2009AA045201 ; 81302350 ; 2013M530495
资助机构National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55833
专题北京大学口腔医学院
北京大学口腔医学院_中心实验室
作者单位Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
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Feng, Zhien,Li, Jian Nan,Wang, Lin,et al. The prognostic value of glycerol-3-phosphate dehydrogenase 1-like expression in head and neck squamous cell carcinoma[J]. HISTOPATHOLOGY,2014,64(3):348-355.
APA Feng, Zhien,Li, Jian Nan,Wang, Lin,Pu, Yin Fei,Wang, Yixiang,&Guo, Chuan Bin.(2014).The prognostic value of glycerol-3-phosphate dehydrogenase 1-like expression in head and neck squamous cell carcinoma.HISTOPATHOLOGY,64(3),348-355.
MLA Feng, Zhien,et al."The prognostic value of glycerol-3-phosphate dehydrogenase 1-like expression in head and neck squamous cell carcinoma".HISTOPATHOLOGY 64.3(2014):348-355.
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