|Frequency of the Apolipoprotein E epsilon 4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study|
|Wang, Xiao1,2; Wang, Huali1,2; Li, Huiying1,2,3; Li, Tao1,2; Yu, Xin1,2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||MILD COGNITIVE IMPAIRMENT ; SPORADIC ALZHEIMERS-DISEASE ; APOE GENOTYPE ; DIAGNOSTIC-CRITERIA ; VASCULAR DEMENTIA ; TYPE-4 ALLELE ; DECLINE ; ASSOCIATION ; ONSET ; RISK|
Objectives: To describe the distribution of apolipoprotein E (APOE) genotypes among an elderly Chinese patient population with memory complaints treated in a memory clinic in Beijing and to compare the epsilon 4 allele frequency among individuals with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and Alzheimer′s disease (AD).
Methods: A total of 385 subjects with memory complaints participated in the study, including 216 patients with AD, 56 with MCI, 17 with SCI, and 96 with other types of cognitive impairment. A total of 75 healthy elderly control subjects were also recruited. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to investigate the APOE genotypes.
Results: The frequency of the epsilon 4 allele was 19.6 percent for the entire sample of patients who had memory complaints. The APOE allele distribution differed between women and men (22.6% and 14.9%, respectively; p<0.05) in the individuals with memory complaints. Compared with the control group (7.3%), the prevalence of the APOE epsilon 4 allele was significantly higher in the AD (23.6%) and MCI (21.4%) groups and was slightly increased in the SCI (14.7%) group.
Conclusions: In the memory clinic, we observed a higher prevalence of the APOE epsilon 4 allele among Chinese AD and MCI patients. A similar trend was observed in patients with SCI. These findings suggest that nondemented APOE epsilon 4 allele carriers with memory complaints may have a greater genetic risk for AD and should be monitored more closely.
|项目编号||30971044 ; 81171018 ; 2007AA02Z421 ; R21AG028180-01A2 ; NIRG-04-1184|
|资助机构||Natural Science Foundation of China ; National Key RD 863 Project ; Fogarty International Center ; Alzheimer&prime ; s Association ; National Institute on Aging|
|作者单位||1.Chaoyang Dist Third Hosp, Beijing, Peoples R China|
2.Peking Univ, Inst Mental Hlth, Dementia Care & Res Ctr, Hosp 6, Beijing 100871, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
|Wang, Xiao,Wang, Huali,Li, Huiying,et al. Frequency of the Apolipoprotein E epsilon 4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study[J]. PLOS ONE,2014,9(6).|
|APA||Wang, Xiao,Wang, Huali,Li, Huiying,Li, Tao,&Yu, Xin.(2014).Frequency of the Apolipoprotein E epsilon 4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study.PLOS ONE,9(6).|
|MLA||Wang, Xiao,et al."Frequency of the Apolipoprotein E epsilon 4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study".PLOS ONE 9.6(2014).|