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学科主题: 精神卫生
题名:
Frequency of the Apolipoprotein E epsilon 4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study
作者: Wang, Xiao1,2; Wang, Huali1,2; Li, Huiying1,2,3; Li, Tao1,2; Yu, Xin1,2
刊名: PLOS ONE
发表日期: 2014-06-10
DOI: 10.1371/journal.pone.0099130
卷: 9, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MILD COGNITIVE IMPAIRMENT ; SPORADIC ALZHEIMERS-DISEASE ; APOE GENOTYPE ; DIAGNOSTIC-CRITERIA ; VASCULAR DEMENTIA ; TYPE-4 ALLELE ; DECLINE ; ASSOCIATION ; ONSET ; RISK
英文摘要:

Objectives: To describe the distribution of apolipoprotein E (APOE) genotypes among an elderly Chinese patient population with memory complaints treated in a memory clinic in Beijing and to compare the epsilon 4 allele frequency among individuals with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and Alzheimer′s disease (AD).

Methods: A total of 385 subjects with memory complaints participated in the study, including 216 patients with AD, 56 with MCI, 17 with SCI, and 96 with other types of cognitive impairment. A total of 75 healthy elderly control subjects were also recruited. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to investigate the APOE genotypes.

Results: The frequency of the epsilon 4 allele was 19.6 percent for the entire sample of patients who had memory complaints. The APOE allele distribution differed between women and men (22.6% and 14.9%, respectively; p<0.05) in the individuals with memory complaints. Compared with the control group (7.3%), the prevalence of the APOE epsilon 4 allele was significantly higher in the AD (23.6%) and MCI (21.4%) groups and was slightly increased in the SCI (14.7%) group.

Conclusions: In the memory clinic, we observed a higher prevalence of the APOE epsilon 4 allele among Chinese AD and MCI patients. A similar trend was observed in patients with SCI. These findings suggest that nondemented APOE epsilon 4 allele carriers with memory complaints may have a greater genetic risk for AD and should be monitored more closely.

语种: 英语
所属项目编号: 30971044 ; 81171018 ; 2007AA02Z421 ; R21AG028180-01A2 ; NIRG-04-1184
项目资助者: Natural Science Foundation of China ; National Key RD 863 Project ; Fogarty International Center ; Alzheimer&prime ; s Association ; National Institute on Aging
WOS记录号: WOS:000340947700066
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55841
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Chaoyang Dist Third Hosp, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Dementia Care & Res Ctr, Hosp 6, Beijing 100871, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Xiao,Wang, Huali,Li, Huiying,et al. Frequency of the Apolipoprotein E epsilon 4 Allele in a Memory Clinic Cohort in Beijing: A Naturalistic Descriptive Study[J]. PLOS ONE,2014,9(6).
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