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学科主题: 基础医学
题名:
Reversal of the gastric effects of nicotine by nitric oxide donor treatment
作者: Ma, JJ; Hou, DQ; Zhang, QB; Korsten, MA
关键词: gastric ulcer ; nitric oxide ; nicotine ; mucus ; gastric mucosal blood flow ; rat
刊名: DIGESTION
发表日期: 2001
卷: 63, 期:2, 页:102-107
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PEPTIC-ULCER ; CIGARETTE-SMOKE ; MUCOSAL DAMAGE ; COLD-RESTRAINT ; RAT STOMACH ; MUCUS ; INFLAMMATION ; HISTAMINE ; INCREASES ; DIFFUSION
英文摘要:

Nicotine intensifies experimental gastric ulceration by reducing gastric mucosal blood flow (GMBF) and mucus. As both these parameters can be improved by nitric oxide (NO), we evaluated the impact of a NO donor in ethanol-induced gastric mucosal injury in rats administered nicotine. A nicotine solution or water was administered for 20 days to Sprague-Dawley rats. NO donor (isosorbide dinitrate) was given 60 and 10 min before preparation of ex vivo gastric chambers and exposure to ethanol. Chronic nicotine intake significantly reduced GMBF and gastric mucus content. Nicotine intensifies ethanol-induced gastric injury and short-term administration of NO donor failed to antagonize the ulcerogenic action from either nicotine or alcohol. In another study, rats drank nicotine solution for 20 days, after which the nicotine was withdrawn and replaced by water for 10 additional days. NO donor was provided during these last 10 days. The gastric effects of nicotine persisted for at least 10 days after nicotine was withdrawn but then these effects could be abolished by prolonged NO treatment. Nicotine reduces plasma nitrite level, but gastric mucosal MPO activity remained unchanged. Our data suggest that nicotine cessation plus a longer period of NO donor administration can completely abolish the gastric effects of nicotine. Copyright (C) 2001 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000167454800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55846
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Vet Adm Med Ctr, Med Program 111, Bronx, NY 10468 USA
2.Beijing Med Univ, Dept Pharmacol, Beijing 100083, Peoples R China
3.Mt Sinai Sch Med, New York, NY USA

Recommended Citation:
Ma, JJ,Hou, DQ,Zhang, QB,et al. Reversal of the gastric effects of nicotine by nitric oxide donor treatment[J]. DIGESTION,2001,63(2):102-107.
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