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学科主题基础医学
Reversal of the gastric effects of nicotine by nitric oxide donor treatment
Ma, JJ; Hou, DQ; Zhang, QB; Korsten, MA
关键词Gastric Ulcer Nitric Oxide Nicotine Mucus Gastric Mucosal Blood Flow Rat
刊名DIGESTION
2001
63期:2页:102-107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PEPTIC-ULCER ; CIGARETTE-SMOKE ; MUCOSAL DAMAGE ; COLD-RESTRAINT ; RAT STOMACH ; MUCUS ; INFLAMMATION ; HISTAMINE ; INCREASES ; DIFFUSION
英文摘要

Nicotine intensifies experimental gastric ulceration by reducing gastric mucosal blood flow (GMBF) and mucus. As both these parameters can be improved by nitric oxide (NO), we evaluated the impact of a NO donor in ethanol-induced gastric mucosal injury in rats administered nicotine. A nicotine solution or water was administered for 20 days to Sprague-Dawley rats. NO donor (isosorbide dinitrate) was given 60 and 10 min before preparation of ex vivo gastric chambers and exposure to ethanol. Chronic nicotine intake significantly reduced GMBF and gastric mucus content. Nicotine intensifies ethanol-induced gastric injury and short-term administration of NO donor failed to antagonize the ulcerogenic action from either nicotine or alcohol. In another study, rats drank nicotine solution for 20 days, after which the nicotine was withdrawn and replaced by water for 10 additional days. NO donor was provided during these last 10 days. The gastric effects of nicotine persisted for at least 10 days after nicotine was withdrawn but then these effects could be abolished by prolonged NO treatment. Nicotine reduces plasma nitrite level, but gastric mucosal MPO activity remained unchanged. Our data suggest that nicotine cessation plus a longer period of NO donor administration can completely abolish the gastric effects of nicotine. Copyright (C) 2001 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000167454800003
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55846
专题北京大学基础医学院_药理学系
作者单位1.Vet Adm Med Ctr, Med Program 111, Bronx, NY 10468 USA
2.Beijing Med Univ, Dept Pharmacol, Beijing 100083, Peoples R China
3.Mt Sinai Sch Med, New York, NY USA
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GB/T 7714
Ma, JJ,Hou, DQ,Zhang, QB,et al. Reversal of the gastric effects of nicotine by nitric oxide donor treatment[J]. DIGESTION,2001,63(2):102-107.
APA Ma, JJ,Hou, DQ,Zhang, QB,&Korsten, MA.(2001).Reversal of the gastric effects of nicotine by nitric oxide donor treatment.DIGESTION,63(2),102-107.
MLA Ma, JJ,et al."Reversal of the gastric effects of nicotine by nitric oxide donor treatment".DIGESTION 63.2(2001):102-107.
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