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学科主题临床医学
Cytokine expression of T cells in chronic myeloid leukemia
Liu, YR; Kleine, HD; Engel, H; Andreeff, M
关键词t Cells Chronic Myeloid Leukemia Cytokine Expression
刊名CHINESE MEDICAL JOURNAL
2000-03-01
113期:3页:232-235
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CHRONIC MYELOGENOUS LEUKEMIA ; COLONY FORMATION ; INTERLEUKIN-4 ; GROWTH ; CSF
英文摘要

Objective to evaluate the function of T cells in chronic myeloid leukemia (CML).

Methods Interleukin-1 beta ( IL-1 beta), interleukin-2 (IL-2), interleukin-3 (IL-3), interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), and granulocyte macrophage-colony stimulating factor( GMCSF) gene expressions were investigated by reverse transcription polymerase chain reaction (RT-PCR) assay in fluorescence active cell sorter (FACS) sorted peripheral blood CD2 +/CD56-T cells from 12 CML patients, 10 meylodysplastic syndrome (MDS) patients and 7 normal individuals.

Results TNF alpha mRNA was transcribed in T cells from all of the CML, MDS and normal individuals. IL-1 beta mRNA was transcribed in T cells from 10 CML, 9 MDS and 6 normal individuals. Low levels of IL-2 and IL-4 mRNA were detected in 5 CML patients. IL-3, IL-6 and GM-CSF mRNA were undetectable in all samples.

Conclusion IL-4 and IL-2 were expressed abnormally in T cells of CML.

语种英语
WOS记录号WOS:000087103400011
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55855
Collection北京大学第二临床医学院_血液科
作者单位1.Beijing Med Univ, Peoples Hosp, Inst Hematol, Beijing 100034, Peoples R China
2.MD Anderson Canc Ctr, Sect Expt Hematol, Houston, TX 77030 USA
Recommended Citation
GB/T 7714
Liu, YR,Kleine, HD,Engel, H,et al. Cytokine expression of T cells in chronic myeloid leukemia[J]. CHINESE MEDICAL JOURNAL,2000,113(3):232-235.
APA Liu, YR,Kleine, HD,Engel, H,&Andreeff, M.(2000).Cytokine expression of T cells in chronic myeloid leukemia.CHINESE MEDICAL JOURNAL,113(3),232-235.
MLA Liu, YR,et al."Cytokine expression of T cells in chronic myeloid leukemia".CHINESE MEDICAL JOURNAL 113.3(2000):232-235.
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