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学科主题基础医学
Antagonists of toll like receptor 4 maybe a new strategy to counteract opioid-induced hyperalgesia and opioid tolerance
Li, Qian
刊名MEDICAL HYPOTHESES
2012-12-01
DOI10.1016/j.mehy.2012.08.021
79期:6页:754-756
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]MORPHINE ANTINOCICEPTIVE TOLERANCE ; NEUROPATHIC PAIN ; SPINAL MICROGLIA ; NALOXONE ; MOUSE ; RATS ; INVOLVEMENT ; INHIBITION ; ACTIVATION ; GENERATION
英文摘要

Long term opioid treatment results in hyperalgesia and tolerance, which is a troublesome phenomenon in clinic application. Recent studies have revealed a critical role of toll-like receptor 4 (TLR4) in the neuropathological process of opioid-induced hyperalgesia and tolerance. TLR4 is predominantly expressed by microglial cells and is a key modulator in the activation of the innate immune system. Activation of TLR4 may initiate the activation of microglia and hence a number of neurotransmitters and neuromodulators that could enhance neuronal excitability are released. Blockade of TLR4 activation by its antagonists alleviate neuropathic pain. We hypothesized that opioid antagonists such as naloxone and naltrexone, which were also demonstrated to be TLR4 antagonist, may have clinic application value in attenuation of opioid-induced hyperalgesia and tolerance. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000311773500013
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55865
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
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Li, Qian. Antagonists of toll like receptor 4 maybe a new strategy to counteract opioid-induced hyperalgesia and opioid tolerance[J]. MEDICAL HYPOTHESES,2012,79(6):754-756.
APA Li, Qian.(2012).Antagonists of toll like receptor 4 maybe a new strategy to counteract opioid-induced hyperalgesia and opioid tolerance.MEDICAL HYPOTHESES,79(6),754-756.
MLA Li, Qian."Antagonists of toll like receptor 4 maybe a new strategy to counteract opioid-induced hyperalgesia and opioid tolerance".MEDICAL HYPOTHESES 79.6(2012):754-756.
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