IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds
Yang, Dongzhi1; Jin, Yu1; Zhou, Yingshan1; Ma, Guiping1; Chen, Xiangmei2; Lu, Fengmin2; Nie, Jun1
关键词biocomposite N-carboxyethyl chitosan chitosan electrospinning hydroxyapatite mineralization
刊名MACROMOLECULAR BIOSCIENCE
2008-03-10
DOI10.1002/mabi.200700221
8期:3页:239-246
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
关键词[WOS]CALCIUM-CARBONATE ; BIOMINERALIZATION ; PRECIPITATION ; COMPOSITE ; MATRICES ; GROWTH ; SYSTEM ; VITRO ; FILMS ; FOAMS
英文摘要

A biocomposite of hydroxyapatite (HAp) with electrospun nanofibrous scaffolds was prepared by using chitosan/polyvinyl alcohol (CS/PVA) and N-carboxyethyl chitosan/PVA (CECS/PVA) electrospun membranes as organic matrix, and HAp was formed in supersaturated CaCl2 and KH2PO4 solution. The influences of carboxylic acid groups in CECS/PVA fibrous scaffold and polyanionic additive poly(acrylic acid) (PAA) in the incubation solution on the crystal distribution of the HAp were investigated. Field-emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy (EDS), wide-angle X-ray diffraction (WAXD), and Fourier transform infrared (FTIR) were used to characterize the morphology and structure of the deposited mineral phase on the scaffolds. it was found that addition of PAA to the mineral solution and use of matrix with carboxylic acid groups promoted mineral gyrowth and distribution of HAp. MTT testing and SEM imaging from mouse fibroblast (I.929) cell culture revealed the attachment and growth of mouse fibroblast on the surface of biocomposite scaffold, and that the cell morphology and viability were satisfactory for the composite to be used in bioapplications.

语种英语
WOS记录号WOS:000254259700014
引用统计
被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55876
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Key Lab Beijing City Preparat & Proc Novel Polyme, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Dongzhi,Jin, Yu,Zhou, Yingshan,et al. In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds[J]. MACROMOLECULAR BIOSCIENCE,2008,8(3):239-246.
APA Yang, Dongzhi.,Jin, Yu.,Zhou, Yingshan.,Ma, Guiping.,Chen, Xiangmei.,...&Nie, Jun.(2008).In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds.MACROMOLECULAR BIOSCIENCE,8(3),239-246.
MLA Yang, Dongzhi,et al."In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds".MACROMOLECULAR BIOSCIENCE 8.3(2008):239-246.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
In situ mineralizati(528KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Dongzhi]的文章
[Jin, Yu]的文章
[Zhou, Yingshan]的文章
百度学术
百度学术中相似的文章
[Yang, Dongzhi]的文章
[Jin, Yu]的文章
[Zhou, Yingshan]的文章
必应学术
必应学术中相似的文章
[Yang, Dongzhi]的文章
[Jin, Yu]的文章
[Zhou, Yingshan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。