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学科主题: 基础医学
题名:
In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds
作者: Yang, Dongzhi1; Jin, Yu1; Zhou, Yingshan1; Ma, Guiping1; Chen, Xiangmei2; Lu, Fengmin2; Nie, Jun1
关键词: biocomposite ; N-carboxyethyl chitosan ; chitosan ; electrospinning ; hydroxyapatite ; mineralization
刊名: MACROMOLECULAR BIOSCIENCE
发表日期: 2008-03-10
DOI: 10.1002/mabi.200700221
卷: 8, 期:3, 页:239-246
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
关键词[WOS]: CALCIUM-CARBONATE ; BIOMINERALIZATION ; PRECIPITATION ; COMPOSITE ; MATRICES ; GROWTH ; SYSTEM ; VITRO ; FILMS ; FOAMS
英文摘要:

A biocomposite of hydroxyapatite (HAp) with electrospun nanofibrous scaffolds was prepared by using chitosan/polyvinyl alcohol (CS/PVA) and N-carboxyethyl chitosan/PVA (CECS/PVA) electrospun membranes as organic matrix, and HAp was formed in supersaturated CaCl2 and KH2PO4 solution. The influences of carboxylic acid groups in CECS/PVA fibrous scaffold and polyanionic additive poly(acrylic acid) (PAA) in the incubation solution on the crystal distribution of the HAp were investigated. Field-emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy (EDS), wide-angle X-ray diffraction (WAXD), and Fourier transform infrared (FTIR) were used to characterize the morphology and structure of the deposited mineral phase on the scaffolds. it was found that addition of PAA to the mineral solution and use of matrix with carboxylic acid groups promoted mineral gyrowth and distribution of HAp. MTT testing and SEM imaging from mouse fibroblast (I.929) cell culture revealed the attachment and growth of mouse fibroblast on the surface of biocomposite scaffold, and that the cell morphology and viability were satisfactory for the composite to be used in bioapplications.

语种: 英语
WOS记录号: WOS:000254259700014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55876
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Key Lab Beijing City Preparat & Proc Novel Polyme, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Dongzhi,Jin, Yu,Zhou, Yingshan,et al. In situ mineralization of hydroxyapatite on electrospun chitosan-based nanofibrous scaffolds[J]. MACROMOLECULAR BIOSCIENCE,2008,8(3):239-246.
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