IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
The Alternative Pathway of Complement Activation May Be Involved in the Renal Damage of Human Anti-Glomerular Basement Membrane Disease
Ma, Rui1,2; Cui, Zhao1; Hu, Shui-Yi1; Jia, Xiao-Yu1; Yang, Rui1; Zheng, Xin1; Ao, Jie1; Liu, Gang1; Liao, Yun-Hua2; Zhao, Ming-Hui1,3
刊名PLOS ONE
2014-03-21
DOI10.1371/journal.pone.0091250
9期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]PROPERDIN BINDS ; MICE ; GLOMERULONEPHRITIS ; NEPHRITIS ; C3 ; CELLS ; DEFICIENCY ; ARTHRITIS ; ANTIBODY ; DEPOSIT
英文摘要

Linear deposition of IgG and complement 3 (C3) along glomerular basement membrane (GBM) is generally revealed in the kidneys of human anti-GBM disease. Our recent studies demonstrated the pathogenic role of complement activation in renal damage of this disease. However, the pathways of complement activation were still paradoxical. In this study, renal biopsy tissues from 10 patients with anti-GBM disease were used to investigate the pathways of complement activation by detecting the deposition of various complement components, including C1q, factor B, factor P (properdin), mannose-binding lectin (MBL), C3d, C4d and C5b-9, using immunohistochemistry and immunofluorescence. We found that C1q, factor B, properdin, C3d, C4d and C5b-9 were detected in all the glomeruli of our patients, along GBM with a linear and/or granular staining pattern. Furthermore, C1q, factor B and properdin co-localized well with C5b-9. The properdin also co-localized well with C3d. However, the deposition of MBL was diffusive in mesangium, GBM, Bowman′s capsule and within crescents and was not co-localized with C5b-9 but partially co-localized with C4d. The intensity of factor B deposition (3.3 vs. 1.2, P<0.001) and C5b-9 deposition (3.2 vs. 1.6, P<0.001) was significantly stronger in the glomeruli with crescent formation, compared with the glomeruli without crescents. The complement system is overall activated via both the alternative pathway and classical pathway in the kidneys of human anti-GBM disease. The alternative pathway might play an important role in complement activation induced renal damage.

语种英语
WOS记录号WOS:000333355300029
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55879
专题北京大学第一临床医学院
北京大学第一临床医学院_肾脏内科
北京大学临床肿瘤学院_药剂科
作者单位1.Peking Univ, Hosp 1, Inst Nephrol,Key Lab Renal Dis, Dept Med,Renal Div,Minist Educ China,Key Lab Chro, Beijing 100871, Peoples R China
2.Guangxi Med Univ, Affiliated Hosp 1, Dept Med, Div Renal, Nanning, Guangxi Zhuang, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
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Ma, Rui,Cui, Zhao,Hu, Shui-Yi,et al. The Alternative Pathway of Complement Activation May Be Involved in the Renal Damage of Human Anti-Glomerular Basement Membrane Disease[J]. PLOS ONE,2014,9(3).
APA Ma, Rui.,Cui, Zhao.,Hu, Shui-Yi.,Jia, Xiao-Yu.,Yang, Rui.,...&Zhao, Ming-Hui.(2014).The Alternative Pathway of Complement Activation May Be Involved in the Renal Damage of Human Anti-Glomerular Basement Membrane Disease.PLOS ONE,9(3).
MLA Ma, Rui,et al."The Alternative Pathway of Complement Activation May Be Involved in the Renal Damage of Human Anti-Glomerular Basement Membrane Disease".PLOS ONE 9.3(2014).
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