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学科主题: 临床医学
题名:
Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer
作者: Zhang, Xinyan; Feng, Jie; Ye, Xue; Yao, Yu; Zhou, Ping; Chen, Xiaoxin
关键词: immunocytokine ; interleukin 2 ; ovarian cancer
刊名: GYNECOLOGIC ONCOLOGY
发表日期: 2006-12-01
DOI: 10.1016/j.ygyno.2006.05.016
卷: 103, 期:3, 页:848-852
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: SINGLE-CHAIN FV ; MONOCLONAL-ANTIBODY ; PROSTATE-CANCER ; INTERLEUKIN-2 ; CARCINOMA ; THERAPY ; FUSION ; ANTIGENS
英文摘要:

Objectives. The purpose of this study was to develop an immunocytokine for immunotherapy of human ovarian cancer.

Methods. The single-chain Fv of a monoclonal antibody, COC183B2, specific for an ovarian carcinoma-associated antigen (OC183B2), was genetically fused with the coding sequence of interleukin 2 (IL-2). The fusion protein, also called immunocytokine, IL-2-183B2scFv, was expressed in CHO cells and examined for its specificity and biological function.

Results. The immunocytokine, IL-2-183B2scFv, retained the functions of both the antibody and IL-2. It was able to target IL-2 to tumor cells that overexpress OC183B2, and stimulate the proliferation of an IL-2-dependent cell line, CTLL-2.

Conclusions. The IL-2-183B2scFv maintains the functions of both IL-2 and antibody. It can be potentially used for immunotherapy of ovarian cancer by delivering a high concentration of IL-2 to OC183B2-expressing ovarian cancer cells. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000242809500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55880
Appears in Collections:北京大学第二临床医学院_妇科肿瘤中心_期刊论文

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作者单位: 1.N Carolina Cent Univ, Canc Res Program, Julius L Chambers Biomed Biotechnol Res Inst, Durham, NC 27707 USA
2.Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Xinyan,Feng, Jie,Ye, Xue,et al. Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer[J]. GYNECOLOGIC ONCOLOGY,2006,103(3):848-852.
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