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Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer
Zhang, Xinyan; Feng, Jie; Ye, Xue; Yao, Yu; Zhou, Ping; Chen, Xiaoxin
关键词Immunocytokine Interleukin 2 Ovarian Cancer
刊名GYNECOLOGIC ONCOLOGY
2006-12-01
DOI10.1016/j.ygyno.2006.05.016
103期:3页:848-852
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]SINGLE-CHAIN FV ; MONOCLONAL-ANTIBODY ; PROSTATE-CANCER ; INTERLEUKIN-2 ; CARCINOMA ; THERAPY ; FUSION ; ANTIGENS
英文摘要

Objectives. The purpose of this study was to develop an immunocytokine for immunotherapy of human ovarian cancer.

Methods. The single-chain Fv of a monoclonal antibody, COC183B2, specific for an ovarian carcinoma-associated antigen (OC183B2), was genetically fused with the coding sequence of interleukin 2 (IL-2). The fusion protein, also called immunocytokine, IL-2-183B2scFv, was expressed in CHO cells and examined for its specificity and biological function.

Results. The immunocytokine, IL-2-183B2scFv, retained the functions of both the antibody and IL-2. It was able to target IL-2 to tumor cells that overexpress OC183B2, and stimulate the proliferation of an IL-2-dependent cell line, CTLL-2.

Conclusions. The IL-2-183B2scFv maintains the functions of both IL-2 and antibody. It can be potentially used for immunotherapy of ovarian cancer by delivering a high concentration of IL-2 to OC183B2-expressing ovarian cancer cells. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000242809500011
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55880
专题北京大学第二临床医学院_妇科肿瘤中心
作者单位1.N Carolina Cent Univ, Canc Res Program, Julius L Chambers Biomed Biotechnol Res Inst, Durham, NC 27707 USA
2.Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China
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GB/T 7714
Zhang, Xinyan,Feng, Jie,Ye, Xue,et al. Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer[J]. GYNECOLOGIC ONCOLOGY,2006,103(3):848-852.
APA Zhang, Xinyan,Feng, Jie,Ye, Xue,Yao, Yu,Zhou, Ping,&Chen, Xiaoxin.(2006).Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer.GYNECOLOGIC ONCOLOGY,103(3),848-852.
MLA Zhang, Xinyan,et al."Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer".GYNECOLOGIC ONCOLOGY 103.3(2006):848-852.
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