学科主题临床医学
Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study
Zhang, Xiao-hui1; Zhu, Xiao-lu1; Niu, Ting2; Sun, Jing3; Liu, Hui4; Feng, Ru4; Yang, Lin-hua5; Wei, Qing2; Ma, Qing-hui3; Wang, Qing-ming1; Feng, Fei-er1; Fu, Hai-xia1; Mo, Xiao-dong1; Lv, Meng1; Huang, Xiao-jun1
关键词Acquired Hemophiliaa Rfviia Fviii Pcc Bleeding Disorder
刊名THROMBOSIS RESEARCH
2015-05-01
DOI10.1016/j.thromres.2015.02.029
135期:5页:835-840
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing ; National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]ACTIVATED FACTOR-VII ; CENTER DOCTORS ORGANIZATION ; RECOMBINANT FACTOR VIIA ; UNITED-KINGDOM ; INHIBITORS ; MANAGEMENT ; DIAGNOSIS ; GUIDELINES ; MULTICENTER ; EFFICACY
英文摘要

Introduction: Acquired haemophilia A (AHA) is an autoimmune disease that potentially leads to severe bleeding and has a high rate of mortality. This collaborative study aimed to assess the efficacy of the co-administration of FVIII and low-dose rFVIIa in patients with AHA.

Materials and Methods: This study retrospectively compared the combined FVIII/low-dose rFVIIa therapy (initial dose range of 25-55 mu g/Kg) with the combined FVIII/PCC therapy and low-dose rFVIIa monotherapy. Adverse drug reactions and recurrent bleeding episodes were also monitored. Crude comparisons and the exact conditional logistic regression were performed to compare the outcomes between three treatment groups.′

Results: First bleeding episodes of 56 consecutive patients from 5 centres were analyzed, and 37 bleeding episodes (66.1%) were determined to be severe. Specifically, the rate of bleeding control was significantly higher with the FVIII/low-dose rFVIIa therapy compared to that of the low-dose rFVIIa alone therapy or the FVIII/PCC therapy (58.3% vs. 41.7% vs. 95.0%, respectively). Analyzing of total 236 bleeding episodes showed a clear positive association between the early initiation of haemostatic treatment and efficacy. No therapy-related adverse events in which thrombosis predominated were reported.

Conclusions: The combination of FVIII and low-dose rFVIIa offers an ideal haemostatic cover and may be promoted as a feasible and safe therapy protocol for patients with AHA. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81270643 ; 81070449 ; 2012BAI38B03 ; 7112139
资助者National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing ; National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing
WOS记录号WOS:000353490800011
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55884
专题北京大学第二临床医学院_北京大学血液病研究所
作者单位1.Beijing Hosp, Dept Haematol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Haematol, Beijing 100044, Peoples R China
3.Sichuan Univ, Dept Haematol, West China Hosp, West China Sch Clin Med, Chengdu 610064, Sichuan, Peoples R China
4.Southern Med Univ, Dept Haematol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
5.Shanxi Med Univ, Hosp 2, Dept Haematol, Taiyuan, Shanxi, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiao-hui,Zhu, Xiao-lu,Niu, Ting,et al. Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study[J]. THROMBOSIS RESEARCH,2015,135(5):835-840.
APA Zhang, Xiao-hui.,Zhu, Xiao-lu.,Niu, Ting.,Sun, Jing.,Liu, Hui.,...&Huang, Xiao-jun.(2015).Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study.THROMBOSIS RESEARCH,135(5),835-840.
MLA Zhang, Xiao-hui,et al."Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study".THROMBOSIS RESEARCH 135.5(2015):835-840.
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