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学科主题: 临床医学
题名:
Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study
作者: Zhang, Xiao-hui1; Zhu, Xiao-lu1; Niu, Ting2; Sun, Jing3; Liu, Hui4; Feng, Ru4; Yang, Lin-hua5; Wei, Qing2; Ma, Qing-hui3; Wang, Qing-ming1; Feng, Fei-er1; Fu, Hai-xia1; Mo, Xiao-dong1; Lv, Meng1; Huang, Xiao-jun1
关键词: Acquired hemophiliaA ; rFVIIa ; FVIII ; PCC ; Bleeding disorder
刊名: THROMBOSIS RESEARCH
发表日期: 2015-05-01
DOI: 10.1016/j.thromres.2015.02.029
卷: 135, 期:5, 页:835-840
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: ACTIVATED FACTOR-VII ; CENTER DOCTORS ORGANIZATION ; RECOMBINANT FACTOR VIIA ; UNITED-KINGDOM ; INHIBITORS ; MANAGEMENT ; DIAGNOSIS ; GUIDELINES ; MULTICENTER ; EFFICACY
英文摘要:

Introduction: Acquired haemophilia A (AHA) is an autoimmune disease that potentially leads to severe bleeding and has a high rate of mortality. This collaborative study aimed to assess the efficacy of the co-administration of FVIII and low-dose rFVIIa in patients with AHA.

Materials and Methods: This study retrospectively compared the combined FVIII/low-dose rFVIIa therapy (initial dose range of 25-55 mu g/Kg) with the combined FVIII/PCC therapy and low-dose rFVIIa monotherapy. Adverse drug reactions and recurrent bleeding episodes were also monitored. Crude comparisons and the exact conditional logistic regression were performed to compare the outcomes between three treatment groups.′

Results: First bleeding episodes of 56 consecutive patients from 5 centres were analyzed, and 37 bleeding episodes (66.1%) were determined to be severe. Specifically, the rate of bleeding control was significantly higher with the FVIII/low-dose rFVIIa therapy compared to that of the low-dose rFVIIa alone therapy or the FVIII/PCC therapy (58.3% vs. 41.7% vs. 95.0%, respectively). Analyzing of total 236 bleeding episodes showed a clear positive association between the early initiation of haemostatic treatment and efficacy. No therapy-related adverse events in which thrombosis predominated were reported.

Conclusions: The combination of FVIII and low-dose rFVIIa offers an ideal haemostatic cover and may be promoted as a feasible and safe therapy protocol for patients with AHA. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81270643 ; 81070449 ; 2012BAI38B03 ; 7112139
项目资助者: National Natural Science Foundation of China ; National Key Technology Support Program ; Natural Science Foundation of Beijing
WOS记录号: WOS:000353490800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55884
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

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作者单位: 1.Beijing Hosp, Dept Haematol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Haematol, Beijing 100044, Peoples R China
3.Sichuan Univ, Dept Haematol, West China Hosp, West China Sch Clin Med, Chengdu 610064, Sichuan, Peoples R China
4.Southern Med Univ, Dept Haematol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
5.Shanxi Med Univ, Hosp 2, Dept Haematol, Taiyuan, Shanxi, Peoples R China

Recommended Citation:
Zhang, Xiao-hui,Zhu, Xiao-lu,Niu, Ting,et al. Combination of FVIII and low-dose rFVIIa improves haemostasis in acquired haemophilia A patients: a collaborative controlled study[J]. THROMBOSIS RESEARCH,2015,135(5):835-840.
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