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学科主题: 临床医学
题名:
Immunohistochemical characterization of neuroendocrine cells in prostate cancer
作者: Huang, Jiaoti; Yao, Jorge L.; di Sant′ Agnese, Anthony; Yang, Qi; Bourne, Patricia A.; Na, Yanqun
关键词: prostate cancer ; neuroendocrine cells ; immunohistochemistry
刊名: PROSTATE
发表日期: 2006-09-15
DOI: 10.1002/pros.20434
卷: 66, 期:13, 页:1399-1406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: ANDROGEN-INDEPENDENT GROWTH ; NEOPLASTIC HUMAN PROSTATE ; ACID-PHOSPHATASE ; DIFFERENTIAL EXPRESSION ; HORMONAL TREATMENT ; CARCINOID-TUMORS ; IN-VITRO ; PROLIFERATION ; BASAL ; P63
英文摘要:

BACKGROUND. Neuroendocrine (NE) cells increase in high grade/stage prostate cancer (PC) and may contribute to androgen-independent cancer. Their immunohistochemical phenotype has not been studied in detail and conflicting results have been reported.

METHODS. PC tissue was stained immunohistochemically for luminal secretory cell-associated cytokeratin, basal cell markers, ki-67, androgen receptor (AR), PSA, prostate acid phosphatase (PAP), and alpha-methylacyl coenzyme A racemase (AMACR).

RESULTS. The NE cells are positive for AE1/AE3, Cam 5.2, and negative for basal cell markers. They are negative for AR, PSA, and Ki-67 but positive for PAP. The benign NE cells are negative for AMACR while the malignant NE cells are positive for AMACR.

CONCLUSIONS. NE cells of PC constitute a unique subset of cancer cells, which have a unique immunohistochemical profile. They do not express AR, consistent with their resistance to hormonal therapy. They are post-mitotic cells but are malignant and part of the tumor.

语种: 英语
WOS记录号: WOS:000240334700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55889
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Univ Rochester, Med Ctr, Dept Pathol, Rochester, NY 14642 USA
2.Beijing Univ, Coll Med, Inst Urol, Beijing, Peoples R China

Recommended Citation:
Huang, Jiaoti,Yao, Jorge L.,di Sant&prime,et al. Immunohistochemical characterization of neuroendocrine cells in prostate cancer[J]. PROSTATE,2006,66(13):1399-1406.
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