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学科主题基础医学
Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation
Liu, Feng-Yu; Qu, Xiao-Xiu; Ding, Xu; Cai, Jie; Jiang, Hong; Wan, You; Han, Ji-Sheng; Xing, Guo-Gang1
关键词5-hydroxytryptamine 5-hydroxytryptamine Receptor Wdr Neurons Spinal Cord Neuropathic Pain Electrophysiology
刊名BRAIN RESEARCH
2010-05-12
DOI10.1016/j.brainres.2010.03.010
1330期:3页:45-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; Chinese Ministry of Education ; National Basic Research Program of China ; National Natural Science Foundation of China ; Chinese Ministry of Education ; National Basic Research Program of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ROSTRAL VENTROMEDIAL MEDULLA ; SEROTONIN RECEPTOR SUBTYPES ; CHRONIC NEUROPATHIC PAIN ; SUPERFICIAL DORSAL-HORN ; PERIPHERAL NEUROPATHY ; GABA-IMMUNOREACTIVITY ; GABAERGIC INHIBITION ; CORD ; NEURONS ; MECHANISMS
英文摘要

The descending serotonergic (5-HT) system is shown to be plastically altered under pathological conditions such as inflammation or peripheral nerve lesion. Although much evidence indicates that the potentiation of descending facilitatory 5-HT pathways may contribute to the development of chronic pain, the inhibition of descending inhibitory 5-HT system may be functionally more important to the development of central sensitization and neuropathic pain. In the present study, we observed that the inhibitory effects of 5-HT and its receptor agonists including 1A, 1B, 3, 4, and probably 2C receptor agonists, on the C-fiber responses of dorsal horn wide dynamic range (WDR) neurons in the spinal cord decreased significantly following spinal nerve ligation (SNL). Furthermore, we found that the antagonistic effects of 5-HT 1B, 2C, 3, and 4 receptor antagonists on the 5-HT-induced inhibition of C-fiber responses of WDR neurons were also attenuated after SNL. In consistent with these observations, we also found an obvious decrease in the content of 5-HT and 5-HIAA, and a marked increase in the turnover rate of 5-HT (5-HIAA/5-HT) in the ipsilateral dorsal half of the lumbar spinal cord after SNL. These data indicate that a loss or decrease in the descending inhibitory 5-HT system upon the spinal processing of nociceptive information appears to occur following spinal nerve injury, and this kind of decrease in the descending inhibitory 5-HT system is proposed to be involved in the development of central sensitization and ultimately to the nerve injury-induced neuropathic pain. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
所属项目编号30370470 ; 30600173 ; 109003 ; 2007CB512501
资助者National Natural Science Foundation of China ; Chinese Ministry of Education ; National Basic Research Program of China ; National Natural Science Foundation of China ; Chinese Ministry of Education ; National Basic Research Program of China
WOS记录号WOS:000277896800005
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55896
专题北京大学基础医学院_神经生物学系
作者单位1.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
2.Minist Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
4.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Feng-Yu,Qu, Xiao-Xiu,Ding, Xu,et al. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation[J]. BRAIN RESEARCH,2010,1330(3):45-60.
APA Liu, Feng-Yu.,Qu, Xiao-Xiu.,Ding, Xu.,Cai, Jie.,Jiang, Hong.,...&Xing, Guo-Gang.(2010).Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation.BRAIN RESEARCH,1330(3),45-60.
MLA Liu, Feng-Yu,et al."Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation".BRAIN RESEARCH 1330.3(2010):45-60.
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