IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Contrast-enhanced MR angiography: does a higher relaxivity MR contrast agent permit a reduction of the dose administered for routine vascular imaging applications?
Xing, Xiaoying1; Zeng, Xiangzhu1; Li, Xuan1; Zhao, Qiang1; Kirchin, Miles A.2; Pirovano, Gianpaolo3; Wang, Xiaoying4; Li, Yuan5; Iezzi, Roberto6; De Cobelli, Francesco7
关键词Magnetic Resonance Angiography Gadobenate Dimeglumine Gadopentetate Dimeglumine Vascular Disease Comparative Trials
刊名RADIOLOGIA MEDICA
2015-02-01
DOI10.1007/s11547-014-0434-8
120期:2页:239-250
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
资助者Bracco Imaging SpA ; Bracco Imaging SpA
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]NEPHROGENIC SYSTEMIC FIBROSIS ; MAGNETIC-RESONANCE ANGIOGRAPHY ; GADOBENATE DIMEGLUMINE ; GADOPENTETATE DIMEGLUMINE ; PERIPHERAL ARTERIES ; LESION DETECTION ; BRAIN-TUMORS ; DOUBLE-BLIND ; 3 TESLA ; MULTICENTER
英文摘要

The authors prospectively compared single dose (0.1 mmol/kg bodyweight) gadobenate dimeglumine with double dose (0.2 mmol/kg bodyweight) gadopentetate dimeglumine for contrast-enhanced magnetic resonance angiography (CE-MRA) in patients with suspected or known steno-occlusive disease of the carotid, renal or peripheral vasculature using an intra-individual crossover study design.

Twenty-eight patients with suspected or known steno-occlusive disease of the carotid (n = 16), renal (n = 5) or peripheral arteries (n = 7) were randomised to receive either 0.1 mmol/kg gadobenate dimeglumine or 0.2 mmol/kg gadopentetate dimeglumine for a first CE-MRA procedure. After 3-5 days all patients underwent a second identical CE-MRA procedure with the other contrast agent. Three blinded readers assessed images for vessel anatomical delineation, disease detection/exclusion, and global preference. Diagnostic performance for detection of a parts per thousand yen51 % stenosis was determined for 20/28 patients who also underwent digital subtraction angiography (DSA). Non-inferiority was assessed using the Wilcoxon signed rank, McNemar and Wald tests. Quantitative (signal-to-noise and contrast-to-noise ratio) enhancement based on 3D maximum intensity projection reconstructions was compared.

No differences were noted for any qualitative parameter. Equivalence was reported for all diagnostic preference end-points. Superiority for gadobenate dimeglumine was reported by all readers for sensitivity for disease detection (80.8-86.5 vs. 75.0-82.7 %). Quantitative enhancement was similar for single dose gadobenate dimeglumine and double dose gadopentetate dimeglumine.

Under identical examination conditions a single 0.1 mmol/kg body weight dose of gadobenate dimeglumine can fully replace a double 0.2 mmol/kg body weight dose of gadopentetate dimeglumine for routine CE-MRA procedures.

语种英语
资助者Bracco Imaging SpA ; Bracco Imaging SpA
WOS记录号WOS:000349910500008
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55903
Collection北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Bracco Imaging SpA, Global Med & Regulatory Affairs, Milan, Italy
3.Bracco Diagnost Inc, Global Med & Regulatory Affairs, Monroe, NJ USA
4.Peking Univ, Dept Radiol, Hosp 1, Beijing 100034, Peoples R China
5.Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200040, Peoples R China
6.Catholic Univ, Dept Bioimaging & Radiol Sci, Inst Radiol, A Gemelli Hosp, I-00168 Rome, Italy
7.Osped San Raffaele, UO Risonanza Magnet, I-20132 Milan, Italy
Recommended Citation
GB/T 7714
Xing, Xiaoying,Zeng, Xiangzhu,Li, Xuan,et al. Contrast-enhanced MR angiography: does a higher relaxivity MR contrast agent permit a reduction of the dose administered for routine vascular imaging applications?[J]. RADIOLOGIA MEDICA,2015,120(2):239-250.
APA Xing, Xiaoying.,Zeng, Xiangzhu.,Li, Xuan.,Zhao, Qiang.,Kirchin, Miles A..,...&De Cobelli, Francesco.(2015).Contrast-enhanced MR angiography: does a higher relaxivity MR contrast agent permit a reduction of the dose administered for routine vascular imaging applications?.RADIOLOGIA MEDICA,120(2),239-250.
MLA Xing, Xiaoying,et al."Contrast-enhanced MR angiography: does a higher relaxivity MR contrast agent permit a reduction of the dose administered for routine vascular imaging applications?".RADIOLOGIA MEDICA 120.2(2015):239-250.
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