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学科主题临床医学
Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol
Ren, Tingting; He, Jinhan; Jiang, Hongfeng; Zu, Luxia; Pu, Shenshen; Guo, Xiaohui; Xu, Guoheng
刊名JOURNAL OF MOLECULAR ENDOCRINOLOGY
2006-08-01
DOI10.1677/jme.1.02061
37期:1页:175-183
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]DIFFERENTIATION-RELATED PROTEIN ; HORMONE-SENSITIVE LIPASE ; SIGNAL-RELATED KINASE ; 3T3-L1 ADIPOCYTES ; ADIPOSE-TISSUE ; INSULIN-RESISTANCE ; INCREASE LIPOLYSIS ; GLUCOSE ; PERILIPIN ; METABOLISM
英文摘要

In patients with type 2 non-insulin-dependent diabetes mellitus (NIDDM), the biguanide, metformin, exerts its antihyperglycemic effect by improving insulin sensitivity, which is associated with decreased level of circulating free fatty acids (FFA). The flux of FFA and glycerol from adipose tissue to the blood stream primarily depends on the lipolysis of triacylglycerols in the adipocytes. Adipocyte lipolysis is physiologically stimulated by catecholamine hormones. Tumor necrosis factor-alpha (TNF-alpha), a cytokine largely expressed in adipose tissue, stimulates chronic lipolysis, which may be associated with increased systemic FFA and insulin resistance in obesity and NIDDM. In this study, we examined the role of metformin in inhibiting lipolytic action upon various lipolytic stimulations in primary rat adipocytes. Treatment with metformin attenuated TNF-alpha-mediated lipolysis by suppressing phosphorylation of extracellular signal-related kinase 1/2 and reversing the downregulation of perilipin protein in TNF-alpha-stimulated adipocytes. The acute lipolytic response to adrenergic stimulation of isoproterenol was also restricted by metformin. A high concentration of glucose in the adipocyte culture promoted the basal rate of glycerol release and significantly enhanced the lipolytic action stimulated by either TNF-alpha or isoproterenol. Metformin not only inhibits the basal lipolysis simulated by high glucose, but also suppresses the high glucose-enhanced lipolysis response to TNF-alpha or isoproterenol. The antilipolytic action in adipocytes could be the mechanism by which cellular action by metformin reduces systemic FFA concentration and thus improves insulin sensitivity in obese patients and the hyperglycemic conditions of NIDDM.

语种英语
WOS记录号WOS:000240020600015
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55904
专题北京大学第一临床医学院_内分泌内科
作者单位1.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
3.Minist Educ China, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
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GB/T 7714
Ren, Tingting,He, Jinhan,Jiang, Hongfeng,et al. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol[J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY,2006,37(1):175-183.
APA Ren, Tingting.,He, Jinhan.,Jiang, Hongfeng.,Zu, Luxia.,Pu, Shenshen.,...&Xu, Guoheng.(2006).Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol.JOURNAL OF MOLECULAR ENDOCRINOLOGY,37(1),175-183.
MLA Ren, Tingting,et al."Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol".JOURNAL OF MOLECULAR ENDOCRINOLOGY 37.1(2006):175-183.
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