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Natural anti-GBM antibodies from normal human sera recognize alpha 3(IV)NC1 restrictively and recognize the same epitopes as anti-GBM antibodies from patients with anti-GBM disease
Yang, Rui; Cui, Zhao; Hellmark, Thomas; Segelmark, Marten; Zhao, Ming-hui; Wang, Hai-yan
关键词Natural Anti-gbm Antibody Antigen Specificity Epitope Mapping
刊名CLINICAL IMMUNOLOGY
2007-08-01
DOI10.1016/j.clim.2007.05.001
124期:2页:207-212
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]RIBOSOMAL-P-AUTOANTIBODIES ; BASEMENT-MEMBRANE ANTIBODY ; GOODPASTURE-DISEASE ; COLLAGEN-IV ; NC1 DOMAIN ; GLOMERULONEPHRITIS ; IDENTIFICATION ; AUTOIMMUNE ; AUTOANTIGEN ; CHAIN
英文摘要

Anti-GBM disease is a rare autoimmune condition characterized by autoantibodies targeting the alpha 3 chain non-collagen 1 domain of type IV collagen (alpha 3(IV)NC1). Recently, we isolated IgG reacting with alpha 3(IV)NC1 from normal healthy human sera. The current study examined the antigen and epitope specificity of these natural autoantibodies (NAA) using recombinant human alpha 1, 3, 5(IV)NC1 and three constructs expressing, previously defined epitope regions designated E-A, E-B and S2, in the alpha 1(IV)NC1 background. The NAA preparations reacted with recombinant human alpha 3(IV) NC1 to the same extent as with purified bovine alpha(IV)NC1, but not with recombinant human alpha 1 and alpha 5 (IV)NC1. NAA preparations recognized the three chimeric proteins (E-A, E-B and S2) yielding similar absorbance values. We conclude that anti-GBM NAA recognize the same major epitopes as anti-GBM antibodies from patients with Goodpasture′s disease. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000248371100012
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55916
专题北京大学第一临床医学院_肾脏内科
作者单位1.Lund Univ, Dept Nephrol, SE-22184 Lund, Sweden
2.Peking Univ, Inst Nephrol, Peking Univ Hosp 1,Minist Hlth China, Dept Med,Renal Div,Key Lab Renal Dis, Beijing 100034, Peoples R China
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GB/T 7714
Yang, Rui,Cui, Zhao,Hellmark, Thomas,et al. Natural anti-GBM antibodies from normal human sera recognize alpha 3(IV)NC1 restrictively and recognize the same epitopes as anti-GBM antibodies from patients with anti-GBM disease[J]. CLINICAL IMMUNOLOGY,2007,124(2):207-212.
APA Yang, Rui,Cui, Zhao,Hellmark, Thomas,Segelmark, Marten,Zhao, Ming-hui,&Wang, Hai-yan.(2007).Natural anti-GBM antibodies from normal human sera recognize alpha 3(IV)NC1 restrictively and recognize the same epitopes as anti-GBM antibodies from patients with anti-GBM disease.CLINICAL IMMUNOLOGY,124(2),207-212.
MLA Yang, Rui,et al."Natural anti-GBM antibodies from normal human sera recognize alpha 3(IV)NC1 restrictively and recognize the same epitopes as anti-GBM antibodies from patients with anti-GBM disease".CLINICAL IMMUNOLOGY 124.2(2007):207-212.
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