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Synthesis and biological activities of diquaternary dipiperazinium salts containing dithiocarboxyl groups
Ge, ZM; Li, RT; Cheng, TM; Cui, JR
关键词Diquaternary Dipiperazinium Salts Containing Dithiocarboxyl Groups Analgesic Sedative Anticancer
刊名ARCHIV DER PHARMAZIE
2001-05-01
334期:5页:173-176
收录类别IC ; SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
英文摘要

A series of diquaternary dipiperazinium salts containing dithiocarboxyl groups 6a-f and 9 were synthesized and evaluated for their analgesic and sedative activities. The result showed that the presence of two quaternary ammonium cations and the distance between them are very important for the activities of the salts. Compound 6b exhibited the best activities (at dose 2 mg/kg, analgesic, 57%; sedative, 59%) among compounds 6a-f. Compound 9 not only showed the most potent analgesic (85.4%, dose 1 mg/kg) and sedative (93.1%, dose 1 mg/kg) activities, but also exhibited anticancer activity against KB (68.7%, dose 10 muM).

语种英语
WOS记录号WOS:000169127500007
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55917
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Ge, ZM,Li, RT,Cheng, TM,et al. Synthesis and biological activities of diquaternary dipiperazinium salts containing dithiocarboxyl groups[J]. ARCHIV DER PHARMAZIE,2001,334(5):173-176.
APA Ge, ZM,Li, RT,Cheng, TM,&Cui, JR.(2001).Synthesis and biological activities of diquaternary dipiperazinium salts containing dithiocarboxyl groups.ARCHIV DER PHARMAZIE,334(5),173-176.
MLA Ge, ZM,et al."Synthesis and biological activities of diquaternary dipiperazinium salts containing dithiocarboxyl groups".ARCHIV DER PHARMAZIE 334.5(2001):173-176.
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