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Refractive error and smoking habits in exudative age-related macular degeneration in a hospital-based setting
Tao, Y.1,2; Jonas, J. B.1
关键词Exudative Age-related Macular Degeneration Hyperopia Smoking Macular Degeneration Visual Impairment
刊名EYE
2010-04-01
DOI10.1038/eye.2009.160
24期:4页:648-652
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]BLUE-MOUNTAINS EYE ; LONG-TERM INCIDENCE ; RISK-FACTORS ; CIGARETTE-SMOKING ; MACULOPATHY ; PROGRESSION ; POPULATION ; ROTTERDAM
英文摘要

Purpose To assess and compare refractive error and smoking habits in patients with exudative age-related macular degeneration (AMD) in a clinical setting.

Methods The clinical comparative study included 379 patients (379 eyes) who underwent intravitreal application of an anti-vascular growth factor drug for the treatment of exudative AMD, and 191 patients without exudative macular degeneration and who underwent surgery for age-related cataract. Smoking status was compared with an age-matched control group of the German population described in the census of 2003. The main outcome measures were refractive error, axial length, and data from a questionnaire on smoking habits.

Results The AMD group compared with the cataract group showed a significantly shorter axial length (23.31 +/- 0.75 vs 24.20 +/- 1.56 mm; P < 0.001) and was significantly more hyperopic (0.65 +/- 2.14 vs -1.71 +/- 4.57 dioptres; P < 0.001). After the exclusion of pseudophakic AMD patients and matching by age and gender, the difference of refractive error and axial length between both groups remained to be statistically significant (P < 0.001). The AMD group and the matched population group did not vary significantly in smoking history (age group: 55-75 years, current smokers: 18.4% vs 16.8% (P = 0.64); former smokers: 23.2% vs 24.9% (P = 0.66); age group > 75 years, current smokers: 6.3% vs 6.4% (P = 0.97); former smokers: 19.7% vs 22.8% (P = 0.25)).

Conclusions In our setting, an association was found between short axial length and AMD. We were not able to confirm the previously reported link between smoking and AMD. Eye (2010) 24, 648-652; doi:10.1038/eye.2009.160; published online 10 July 2009

语种英语
WOS记录号WOS:000276701300021
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55921
专题北京大学第二临床医学院_眼科
作者单位1.Univ Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Tao, Y.,Jonas, J. B.. Refractive error and smoking habits in exudative age-related macular degeneration in a hospital-based setting[J]. EYE,2010,24(4):648-652.
APA Tao, Y.,&Jonas, J. B..(2010).Refractive error and smoking habits in exudative age-related macular degeneration in a hospital-based setting.EYE,24(4),648-652.
MLA Tao, Y.,et al."Refractive error and smoking habits in exudative age-related macular degeneration in a hospital-based setting".EYE 24.4(2010):648-652.
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