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学科主题基础医学
ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries
Wang, Li2; Zheng, Jingang3; Bai, Xue2; Liu, Bo2; Liu, Chuan-ju4,5; Xu, Qingbo6; Zhu, Yi2; Wang, Nanping2; Kong, Wei1,2; Wang, Xian2
关键词metalloproteinase vascular smooth muscle cell migration neointima formation extracellular matrix
刊名CIRCULATION RESEARCH
2009-03-13
DOI10.1161/CIRCRESAHA.108.188425
104期:5页:688-U247
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Hematology ; Peripheral Vascular Disease
资助者National Natural Science Foundation of the People&prime ; s Republic of China ; Natural Science Foundation of Beijing ; Ministry of Education of China ; National Basic Research Program of the People&prime ; s Republic of China ; Chang Jiang Scholars Program ; National Natural Science Foundation of the People&prime ; s Republic of China ; Natural Science Foundation of Beijing ; Ministry of Education of China ; National Basic Research Program of the People&prime ; s Republic of China ; Chang Jiang Scholars Program
研究领域[WOS]Cardiovascular System & Cardiology ; Hematology
关键词[WOS]OLIGOMERIC MATRIX PROTEIN ; RNA INTERFERENCE ; METALLOPROTEINASE ; DISEASE ; GROWTH ; MATRIX-METALLOPROTEINASE-9 ; HYPERPLASIA ; DEGRADATION ; INHIBITION ; MECHANISMS
英文摘要

The migration of vascular smooth muscle cells (VSMCs) plays an essential role during the development of atherosclerosis and restenosis. Extensive studies have implicated the importance of extracellular matrix (ECM)degrading proteinases in VSMC migration. A recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), is capable of degrading vascular ECM proteins. Here, we sought to determine whether ADAMTS-7 is involved in VSMC migration and neointima formation in response to vascular injury. ADAMTS-7 protein accumulated preferentially in neointima of the carotid artery wall after balloon injury. In primary VSMCs, ADAMTS-7 level was enhanced by the proinflammatory cytokine tumor necrosis factor alpha and growth factor platelet-derived growth factor-BB. ADAMTS-7 overexpression greatly accelerated and small interfering RNA knockdown markedly retarded VSMC migration/invasion in vitro. In addition, luminal delivery of ADAMTS-7 adenovirus to carotid arteries exacerbated intimal thickening nearly sixfold 7 days after injury. Conversely, perivascular administration of ADAMTS-7 small interfering RNA but not scramble small interfering RNA to injured arteries attenuated intimal thickening by 50% at 14 days after injury. Furthermore, ADAMTS-7 mediated degradation of the vascular ECM cartilage oligomeric matrix protein (COMP) in injured vessels. Replenishing COMP circumvented the promigratory effect of ADAMTS-7 on VSMCs. Enforced expression of COMP significantly suppressed VSMC migration and neointima formation postinjury, which indicates that ADAMTS-7 facilitated intimal hyperplasia through degradation of inhibitory matrix protein COMP. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and postangioplasty restenosis. (Circ Res. 2009; 104: 688-698.)

语种英语
所属项目编号30670849 ; 30821001 ; 7072039 ; 2006CB503802
资助者National Natural Science Foundation of the People&prime ; s Republic of China ; Natural Science Foundation of Beijing ; Ministry of Education of China ; National Basic Research Program of the People&prime ; s Republic of China ; Chang Jiang Scholars Program ; National Natural Science Foundation of the People&prime ; s Republic of China ; Natural Science Foundation of Beijing ; Ministry of Education of China ; National Basic Research Program of the People&prime ; s Republic of China ; Chang Jiang Scholars Program
WOS记录号WOS:000264125900017
引用统计
被引频次:106[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55922
专题基础医学院_生理学与病理生理学系
作者单位1.NYU, Sch Med, Dept Orthopaed Surg, New York, NY 10003 USA
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.NYU, Sch Med, Dept Cell Biol, New York, NY 10003 USA
4.Peking Univ, Basic Med Coll, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100083, Peoples R China
5.China Japan Friendship Hosp, Dept Cardiol, Beijing, Peoples R China
6.Kings Coll London, Div Cardiovasc, James Black Ctr, London, England
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GB/T 7714
Wang, Li,Zheng, Jingang,Bai, Xue,et al. ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries[J]. CIRCULATION RESEARCH,2009,104(5):688-U247.
APA Wang, Li.,Zheng, Jingang.,Bai, Xue.,Liu, Bo.,Liu, Chuan-ju.,...&Wang, Xian.(2009).ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries.CIRCULATION RESEARCH,104(5),688-U247.
MLA Wang, Li,et al."ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries".CIRCULATION RESEARCH 104.5(2009):688-U247.
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