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学科主题: 基础医学
题名:
LncRNA Pathway Involved in Premature Preterm Rupture of Membrane (PPROM): An Epigenomic Approach to Study the Pathogenesis of Reproductive Disorders
作者: Luo, Xiucui1; Shi, Qingxi1; Gui, Yang1; Pan, Jing1; Huai, Maofang1; Liu, Meilin1; Dong, Ziqing1; Zhang, Meijiao1; Wang, Leilei1; Gu, Ying1; Zhong, Julia2; Zhao, Xinliang4; Jenkins, Edmund C.3; Brown, W. Ted3; Zhong, Nanbert1,3,4,5,6
刊名: PLOS ONE
发表日期: 2013-11-27
DOI: 10.1371/journal.pone.0079897
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: LONG NONCODING RNAS ; NECROSIS-FACTOR-ALPHA ; FETAL MEMBRANES ; ANTISENSE RNA ; INTACT MEMBRANES ; POLYMORPHISM ; EXPRESSION ; GENE ; ASSOCIATION ; ANRIL
英文摘要:

Preterm birth (PTB) is a live birth delivered before 37 weeks of gestation (GW). About one-third of PTBs result from the preterm premature rupture of membranes (PPROM). Up to the present, the pathogenic mechanisms underlying PPROM are not clearly understood. Here, we investigated the differential expression of long chain non-coding RNAs (lncRNAs) in placentas of PTBs with PPROM, and their possible involvement in the pathogenic pathways leading to PPROM. A total number of 1954, 776, and 1050 lncRNAs were identified with a microarray from placentas of PPROM (group A), which were compared to full-term birth (FTB) (group B), PTB (group C), and premature rupture of membrane (PROM) (group D) at fullterm, respectively. Instead of investigating the individual pathogenic role of each lncRNA involved in the molecular mechanism underlying PPROM, we have focused on investigating the metabolic pathways and their functions to explore what is the likely association and how they are possibly involved in the development of PPROM. Six groups, including upregulation and down-regulation in the comparisons of A vs. B, A vs. C, and A vs. D, of pathways were analyzed. Our results showed that 22 pathways were characterized as up-regulated 7 down-regulated in A vs. C, 18 up-regulated and 15 down-regulated in A vs. D, and 33 up-regulated and 7 down-regulated in A vs. B. Functional analysis showed pathways of infection and inflammatory response, ECM-receptor interactions, apoptosis, actin cytoskeleton, and smooth muscle contraction are the major pathogenic mechanisms involved in the development of PPROM. Characterization of these pathways through identification of lncRNAs opened new avenues for further investigating the epigenomic mechanisms of lncRNAs in PPROM as well as PTB.

语种: 英语
项目资助者: Lianyungang Maternal and Children&prime ; s Hospital ; March of Dimes Global Network for Maternal and Infant Health (MOD-GNMIH) ; Peking University Center of Medical Genetics (PUCMG) ; New York State Office for People with Developmental Disabilities (NYS OPWDD)
WOS记录号: WOS:000327652100018
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55924
Appears in Collections:基础医学院_北京大学医学遗传中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Med Genet, Beijing 100871, Peoples R China
2.March Dimes Global Network Maternal & Infant Hlth, White Plains, NY USA
3.Hunter Coll High Sch, New York, NY USA
4.Lianyungang Maternal & Childrens Hosp, Ctr Translat Med Maternal & Childrens Hlth, Lianyungang, Jiangsu, Peoples R China
5.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA
6.Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200030, Peoples R China

Recommended Citation:
Luo, Xiucui,Shi, Qingxi,Gui, Yang,et al. LncRNA Pathway Involved in Premature Preterm Rupture of Membrane (PPROM): An Epigenomic Approach to Study the Pathogenesis of Reproductive Disorders[J]. PLOS ONE,2013,8(11).
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