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学科主题: 精神卫生
题名:
Abnormal resting-state functional connectivity patterns of the putamen in medication-naive children with attention deficit hyperactivity disorder
作者: Cao, Xiaohua1,2; Cao, Qingjiu1,2; Long, Xiangyu3; Sun, Li1,2; Sui, Manqiu1,2; Zhu, Chaozhe3; Zuo, Xinian3; Zang, Yufeng3; Wang, Yufeng1,2
关键词: Attention deficit hyperactivity disorder ; Functional magnetic resonance imaging ; Resting state ; Functional connectivity ; Putamen
刊名: BRAIN RESEARCH
发表日期: 2009-11-25
DOI: 10.1016/j.brainres.2009.08.029
卷: 1303, 页:195-206
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBRAL-BLOOD-FLOW ; DEFICIT/HYPERACTIVITY DISORDER ; MAGNETIC-RESONANCE ; BASAL GANGLIA ; DEFAULT-MODE ; HUMAN BRAIN ; CORTICOSTRIATAL CIRCUITS ; RESPONSE-INHIBITION ; HUMAN STRIATUM ; FMRI EVIDENCE
英文摘要:

Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-state functional magnetic resonance imaging (fMRI) data to examine the differences in functional connectivity of the putamen between medication-naive children with ADHD and normal children. Positive functional connectivity with the putamen-ROIs was seen in bilateral sensorimotor area, prefrontal cortex, insula, superior temporal gyrus and subcortical regions and negative functional connectivity was located in bilateral parietal and occipital cortex as well as clusters in the frontal, middle temporal cortex and cerebellum. Group comparison showed that decreases in functional connectivity with the putamen-ROIs were observed in ADHD relative to the controls, except for the right globus pallidus/thalamus, which showed increased positive connectivity with left putamen-ROI. For children with ADHD, areas exhibiting decreased positive functional connectivity with left putamen-ROI were seen in right frontal and limbic regions, and regions showing decreased negative connectivity with the putamen-ROIs were observed in areas belonging to the default mode network (for left putamen-ROI, including right cerebellum and right temporal lobe; for right putamen-ROI, including left cerebellum and right precuneus). The above results suggest that abnormal functional relationships between the putamen and the cortical-striatal-thalamic circuits as well as the default mode network may underlie the pathological basis of ADHD. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30770774 ; 30621130074 ; 200802073 ; 2007BAI17B03 ; 2008AA02Z405
项目资助者: National Natural Sciences Foundation of China (NSFC) ; Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; 863 program
WOS记录号: WOS:000272254200020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55927
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

Recommended Citation:
Cao, Xiaohua,Cao, Qingjiu,Long, Xiangyu,et al. Abnormal resting-state functional connectivity patterns of the putamen in medication-naive children with attention deficit hyperactivity disorder[J]. BRAIN RESEARCH,2009,1303:195-206.
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