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学科主题: 公共卫生
题名:
Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China
作者: Tan, Jie1; Liu, Ai Ping2; Sun, Chao3; Bai, Yun Fei4; Lv, Fuzhen1
关键词: A disintegrin and metalloproteinase 33 ; chronic obstructive pulmonary disease ; Mongolian population of China ; single nucleotide polymorphisms
刊名: ANNALS OF HUMAN BIOLOGY
发表日期: 2014
DOI: 10.3109/03014460.2013.821165
卷: 41, 期:1, 页:9-14
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anthropology ; Biology ; Public, Environmental & Occupational Health
研究领域[WOS]: Anthropology ; Life Sciences & Biomedicine - Other Topics ; Public, Environmental & Occupational Health
关键词[WOS]: SINGLE-NUCLEOTIDE POLYMORPHISMS ; OBSTRUCTIVE PULMONARY-DISEASE ; LUNG-FUNCTION DECLINE ; BRONCHIAL HYPERRESPONSIVENESS ; ASTHMA ; RISK ; HISTORY ; T1
英文摘要:

Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality, influenced by both environmental and genetic factors. ADAM33 gene has been found to be associated with asthma, declined lung function and COPD.

Aim: The aim of this study was to find out if SNPs in ADAM33 (V4, T+1, T1, T2, S1, S2, Q-1 and F+1) play any role in genetic susceptibility to COPD in the Mongolian population of China.

Subjects and methods: Two hundred and fifteen Mongolian COPD patients and 223 Mongolian healthy individuals were recruited for the study. Eight polymorphic loci (V4, T+1, T2, T1, S2, S1, Q-1, and F+1) of ADAM33 were selected for genotyping. Genotyping was carried out using the Polymerase Chain Reaction and Restriction Fragment Length polymorphism (PCR-RFLP) method.

Results: Seven SNPs in ADAM33 were associated with COPD (T+1, p = 0.014; T2, p = 0.018; T1, p = 0.048; S2, p = 0.003; S1, p = 0.000; Q-1, p = 0.000 and F+1, p = 0.000), even after Bonferroni correction, SNPs S2, S1, Q-1 and F+1 remained significant. Haplotype analysis showed that the frequencies of haplotype H1 (GGAGGGT), H5 (GGAGGGC) and H10 (GGGGAGT) were significantly higher in the COPD group than in the control group (p = 0.002, 0.031 and 0.009, respectively). In contrast, the haplotype H11 (GGACAGC) was more common in the control group than in the case group (p = 0.015).

Conclusions: Seven SNPs in ADAM33 were associated with COPD in the Mongolian population of China.

语种: 英语
WOS记录号: WOS:000328105200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55929
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Harbin Med Univ, Dept Resp, Affiliated Hosp 2, Harbin 150081, Peoples R China
2.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Inner Mongolia Med Coll, Affiliated Hosp 2, Hohhot 010050, Inner Mongolia, Peoples R China
4.Inner Mongolia Med Coll, Affiliated Hosp, Dept Otolaryngol, Hohhot 010050, Inner Mongolia, Peoples R China

Recommended Citation:
Tan, Jie,Liu, Ai Ping,Sun, Chao,et al. Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China[J]. ANNALS OF HUMAN BIOLOGY,2014,41(1):9-14.
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