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Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China
Tan, Jie1; Liu, Ai Ping2; Sun, Chao3; Bai, Yun Fei4; Lv, Fuzhen1
关键词a Disintegrin And Metalloproteinase 33 Chronic Obstructive Pulmonary Disease Mongolian Population Of China Single Nucleotide Polymorphisms
刊名ANNALS OF HUMAN BIOLOGY
2014
DOI10.3109/03014460.2013.821165
41期:1页:9-14
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anthropology ; Biology ; Public, Environmental & Occupational Health
研究领域[WOS]Anthropology ; Life Sciences & Biomedicine - Other Topics ; Public, Environmental & Occupational Health
关键词[WOS]SINGLE-NUCLEOTIDE POLYMORPHISMS ; OBSTRUCTIVE PULMONARY-DISEASE ; LUNG-FUNCTION DECLINE ; BRONCHIAL HYPERRESPONSIVENESS ; ASTHMA ; RISK ; HISTORY ; T1
英文摘要

Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality, influenced by both environmental and genetic factors. ADAM33 gene has been found to be associated with asthma, declined lung function and COPD.

Aim: The aim of this study was to find out if SNPs in ADAM33 (V4, T+1, T1, T2, S1, S2, Q-1 and F+1) play any role in genetic susceptibility to COPD in the Mongolian population of China.

Subjects and methods: Two hundred and fifteen Mongolian COPD patients and 223 Mongolian healthy individuals were recruited for the study. Eight polymorphic loci (V4, T+1, T2, T1, S2, S1, Q-1, and F+1) of ADAM33 were selected for genotyping. Genotyping was carried out using the Polymerase Chain Reaction and Restriction Fragment Length polymorphism (PCR-RFLP) method.

Results: Seven SNPs in ADAM33 were associated with COPD (T+1, p = 0.014; T2, p = 0.018; T1, p = 0.048; S2, p = 0.003; S1, p = 0.000; Q-1, p = 0.000 and F+1, p = 0.000), even after Bonferroni correction, SNPs S2, S1, Q-1 and F+1 remained significant. Haplotype analysis showed that the frequencies of haplotype H1 (GGAGGGT), H5 (GGAGGGC) and H10 (GGGGAGT) were significantly higher in the COPD group than in the control group (p = 0.002, 0.031 and 0.009, respectively). In contrast, the haplotype H11 (GGACAGC) was more common in the control group than in the case group (p = 0.015).

Conclusions: Seven SNPs in ADAM33 were associated with COPD in the Mongolian population of China.

语种英语
WOS记录号WOS:000328105200002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55929
专题北京大学公共卫生学院
作者单位1.Harbin Med Univ, Dept Resp, Affiliated Hosp 2, Harbin 150081, Peoples R China
2.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Inner Mongolia Med Coll, Affiliated Hosp 2, Hohhot 010050, Inner Mongolia, Peoples R China
4.Inner Mongolia Med Coll, Affiliated Hosp, Dept Otolaryngol, Hohhot 010050, Inner Mongolia, Peoples R China
推荐引用方式
GB/T 7714
Tan, Jie,Liu, Ai Ping,Sun, Chao,et al. Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China[J]. ANNALS OF HUMAN BIOLOGY,2014,41(1):9-14.
APA Tan, Jie,Liu, Ai Ping,Sun, Chao,Bai, Yun Fei,&Lv, Fuzhen.(2014).Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China.ANNALS OF HUMAN BIOLOGY,41(1),9-14.
MLA Tan, Jie,et al."Association of ADAM33 gene polymorphisms with COPD in the Mongolian population of China".ANNALS OF HUMAN BIOLOGY 41.1(2014):9-14.
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