|Helicobacter pylori infection in rural China: demographic, lifestyle and environmental factors|
|Brown, LM; Thomas, TL; Ma, JL; Chang, YS; You, WC; Liu, WD; Zhang, L; Pee, D; Gail, MH|
|关键词||Helicobacter Pylori Risk Factors Aetiology Transmission|
|刊名||INTERNATIONAL JOURNAL OF EPIDEMIOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Public, Environmental & Occupational Health|
|研究领域[WOS]||Public, Environmental & Occupational Health|
|关键词[WOS]||PRECANCEROUS GASTRIC-LESIONS ; STOMACH-CANCER ; HIGH-RISK ; ALCOHOL-CONSUMPTION ; CIGARETTE-SMOKING ; ALLIUM VEGETABLES ; LIVING-CONDITIONS ; ACTIVE INFECTION ; LIFE-STYLE ; PREVALENCE|
Background Although Helicobacter pylori is one of the most common human bacterial infections worldwide, its mode of transmission is unclear.
Methods To investigate possible associations between H. pylori infection and demographic, lifestyle, and environmental factors in a rural Chinese population, a cross-sectional survey was administered to 3288 adults (1994 seropositive, 1019 seronegative, 275 indeterminate) from 13 villages in Linqu County, Shandong Province, China.
Results Helicobacter pylori prevalence was elevated for: infrequent handwashing before meals (OR = 1.7, 95% CI: 1.0-3.0), crowding (i.e. sharing a bed with >2 people [OR = 2.3, 95% CI: 1.3-4.2]), washing/bathing in a pond or ditch (OR = 1.5, 95% CI: 1.0-2.4), and medium (OR = 1.6, 95% CI: 1.3-2.0) and low (OR = 2.3, 95% CI: 1.9-2.9) compared to high village education level, and reduced for never being married or divorced (OR = 0.4, 95% CI: 0.2-1.0). There was also a suggestion that source of drinking water, especially water from a shallow village well might be related to H. pylori seropositivity. There was no evidence of an association between H. pylori prevalence and alcohol or tobacco use, raw fruit and vegetable intake, or individual social class measures.
Conclusions The results of this study suggest that person-to-person transmission is the most plausible route of H. pylori infection in this rural Chinese population, but waterborne exposures deserve further investigation.
|作者单位||1.Beijing Univ, Sch Oncol, Beijing 100034, Peoples R China|
2.Linqu Publ Hlth Bur, Linqu 262600, Shandong Provin, Peoples R China
3.IMS Inc, Rockville, MD 20852 USA
4.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
5.Beijing Univ, Beijing Inst Canc Res, Beijing 100034, Peoples R China
|Brown, LM,Thomas, TL,Ma, JL,et al. Helicobacter pylori infection in rural China: demographic, lifestyle and environmental factors[J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2002,31(3):638-646.|
|APA||Brown, LM.,Thomas, TL.,Ma, JL.,Chang, YS.,You, WC.,...&Gail, MH.(2002).Helicobacter pylori infection in rural China: demographic, lifestyle and environmental factors.INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,31(3),638-646.|
|MLA||Brown, LM,et al."Helicobacter pylori infection in rural China: demographic, lifestyle and environmental factors".INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 31.3(2002):638-646.|