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学科主题: 临床医学
题名:
Calcium channel blockers and modulation of innate immunity
作者: Liu, Wenling; Matsumori, Akira1
关键词: calcium channel blockers ; cardiomyopathy ; innate immunity ; myocarditis
刊名: CURRENT OPINION IN INFECTIOUS DISEASES
发表日期: 2011-06-01
DOI: 10.1097/QCO.0b013e3283463e5b
卷: 24, 期:3, 页:254-258
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: DILATED CARDIOMYOPATHY ; CARDIAC MYOCYTES ; MYOCARDITIS ; ACTIVATION ; HEART ; AUTOANTIBODIES ; EXPRESSION ; ENDOTOXIN ; CELLS ; ANTAGONISTS
英文摘要:

Purpose of review

Researchers and physicians are gaining more understanding of the utility of calcium channel blockers (CCBs) especially in modulation of innate immunity, and choose suitable ones in clinical practice. This review summarizes the recent related research findings.

Recent findings

Sustained and/or dysregulated expression of pro-inflammatory cytokines is sufficient to produce tissue injury and provoke overt cardiac decompensation. The important question that remains to be addressed is whether or not it will be possible to modulate the inappropriate or maladaptive consequences of innate immune activation and pro-inflammatory cytokine expression in the mammalian heart. CCBs, such as nifedipine, amlodipine, diltiazem, and verapamil, promote the relaxation of cardiac and smooth muscle cells by inhibiting calcium influx through calcium channels and calcium release from intracellular stores, and are commonly used in the treatment of cardiovascular disorders. Recently, several in-vitro studies have shown that, besides the effects they exert on muscle cells, CCBs also suppress the activation of various participants in immune reactions, including T cells, mast cells and macrophages, suggesting that they can be immunosuppressant.

Summary

CCBs maybe suppress the activation of various participants in immune reactions.

语种: 英语
WOS记录号: WOS:000289773600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55937
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Tokyo Med & Dent Univ, Shinjuku Ku, Tokyo 1600023, Japan

Recommended Citation:
Liu, Wenling,Matsumori, Akira. Calcium channel blockers and modulation of innate immunity[J]. CURRENT OPINION IN INFECTIOUS DISEASES,2011,24(3):254-258.
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