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学科主题临床医学
Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China
Ge, Shu-Hua1; Wan, Zhe2,3; Li, Juan1,4; Xu, Jianping1,5; Li, Ruo-Yu2,3; Bai, Feng-Yan1
刊名ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2010-08-01
DOI10.1128/AAC.00118-10
54期:8页:3126-3131
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Microbiology ; Pharmacology & Pharmacy
关键词[WOS]ANTIFUNGAL SUSCEPTIBILITY ; IN-VITRO ; STRAINS ; FLUCONAZOLE ; VAGINITIS ; RECURRENT ; MICROSATELLITE ; ITRACONAZOLE ; PREVALENCE ; PROFILE
英文摘要

The relationship between susceptibilities to fluconazole and itraconazole and microsatellite CAI genotypes were examined from a total of 154 Candida albicans isolates (97 isolates causing vulvovaginitis in Chinese women and 6 vaginal isolates and 51 oral cavity isolates from asymptomatic carriers). The two dominant genotypes, CAI 30-45 (45 isolates) and CAI 32-46 (33 isolates), associated with vulvovaginitis showed significantly different azole susceptibility patterns with strong statistical support. CAI 32-46 isolates were usually less susceptible to both fluconazole and itraconazole than CAI 30-45 isolates and than the oral isolates with other diversified CAI genotypes. Remarkably different mutation patterns in the azole target gene ERG11 were correspondingly observed among C. albicans isolates representing different genotypes and sources. Isolates with the same or similar CAI genotypes usually possessed identical or phylogenetically closely related ERG11 sequences. Loss of heterozygosity in ERG11 was observed in all the CAI 32-46 isolates but not in the CAI 30-45 isolates and most of the oral isolates sequenced. Compared with the ERG11 sequence of strain SC5314 (X13296), two homozygous missense mutations (G487T and T916C) leading to two amino acid changes (A114S and Y257H) in Erg11p were found in CAI 32-46 isolates. The correlation between azole susceptibility and C. albicans genotype may be of potential therapeutic significance.

语种英语
WOS记录号WOS:000279963300008
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55938
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Chinese Acad Sci, Inst Microbiol, Key Lab Systemat Mycol & Lichenol, Beijing 100101, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Res Ctr Med Mycol, Beijing 100034, Peoples R China
4.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China
5.McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada
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GB/T 7714
Ge, Shu-Hua,Wan, Zhe,Li, Juan,et al. Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2010,54(8):3126-3131.
APA Ge, Shu-Hua,Wan, Zhe,Li, Juan,Xu, Jianping,Li, Ruo-Yu,&Bai, Feng-Yan.(2010).Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,54(8),3126-3131.
MLA Ge, Shu-Hua,et al."Correlation between Azole Susceptibilities, Genotypes, and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54.8(2010):3126-3131.
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