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学科主题: 临床医学
题名:
Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation
作者: Bao, Y.; Xiu, D. R.
刊名: MEDICAL HYPOTHESES
发表日期: 2013-07-01
DOI: 10.1016/j.mehy.2013.03.037
卷: 81, 期:1, 页:101-103
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: REGULATORY B-CELLS ; VERSUS-HOST-DISEASE ; T-CELLS ; IMMUNE-RESPONSES ; LIVER-TRANSPLANTATION ; AUTOIMMUNITY ; RECIPIENTS ; CD4(+) ; INFLAMMATION ; PHENOTYPE
英文摘要:

Chronic rejection occurs between almost all MHC-mismatched donors and recipients after transplantation. Immunosuppressive agents have been administrated indiscriminately to manage potential rejection, but complications from lifelong immunosuppressive therapy threaten transplant recipients. Recent studies demonstrated that a number of regulatory B cells (B10 cells) negatively regulate T cell mediated immune responses without inducing systemic immune suppression. Therefore, we propose that adaptive transfer of B10 cells suppresses alloreactive CD8(+) cytotoxic T cell activation induced by allogeneic solid organ transplantation, reduces T cell mediated rejection and prolongs allograft survival. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: ZR09-6-02
项目资助者: National nature science fund
WOS记录号: WOS:000321093300022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55945
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Surg, Beijing 100191, Peoples R China

Recommended Citation:
Bao, Y.,Xiu, D. R.. Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation[J]. MEDICAL HYPOTHESES,2013,81(1):101-103.
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