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学科主题临床医学
Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation
Bao, Y.; Xiu, D. R.
刊名MEDICAL HYPOTHESES
2013-07-01
DOI10.1016/j.mehy.2013.03.037
81期:1页:101-103
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]REGULATORY B-CELLS ; VERSUS-HOST-DISEASE ; T-CELLS ; IMMUNE-RESPONSES ; LIVER-TRANSPLANTATION ; AUTOIMMUNITY ; RECIPIENTS ; CD4(+) ; INFLAMMATION ; PHENOTYPE
英文摘要

Chronic rejection occurs between almost all MHC-mismatched donors and recipients after transplantation. Immunosuppressive agents have been administrated indiscriminately to manage potential rejection, but complications from lifelong immunosuppressive therapy threaten transplant recipients. Recent studies demonstrated that a number of regulatory B cells (B10 cells) negatively regulate T cell mediated immune responses without inducing systemic immune suppression. Therefore, we propose that adaptive transfer of B10 cells suppresses alloreactive CD8(+) cytotoxic T cell activation induced by allogeneic solid organ transplantation, reduces T cell mediated rejection and prolongs allograft survival. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000321093300022
项目编号ZR09-6-02
资助机构National nature science fund
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55945
专题北京大学第三临床医学院_普通外科
作者单位Peking Univ, Hosp 3, Dept Surg, Beijing 100191, Peoples R China
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GB/T 7714
Bao, Y.,Xiu, D. R.. Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation[J]. MEDICAL HYPOTHESES,2013,81(1):101-103.
APA Bao, Y.,&Xiu, D. R..(2013).Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation.MEDICAL HYPOTHESES,81(1),101-103.
MLA Bao, Y.,et al."Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation".MEDICAL HYPOTHESES 81.1(2013):101-103.
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