北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Uric acid and incident chronic kidney disease in a large health check-up population in Taiwan
作者: Wang, Shengfeng; Shu, Zheng; Tao, Qiushan; Yu, Canqing; Zhan, Siyan; Li, Liming
关键词: chronic kidney disease ; clinical epidemiology ; glomerular filtration rate ; uric acid
刊名: NEPHROLOGY
发表日期: 2011-11-01
DOI: 10.1111/j.1440-1797.2011.01513.x
卷: 16, 期:8, 页:767-776
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; STAGE RENAL-DISEASE ; ALL-CAUSE MORTALITY ; CARDIOVASCULAR-DISEASE ; SERUM CREATININE ; ESSENTIAL-HYPERTENSION ; DIABETES-MELLITUS ; SCREENED COHORT ; BLOOD-PRESSURE ; RISK-FACTOR
英文摘要:

Aim: Uric acid (UA) is strongly associated with the confirmed chronic kidney disease (CKD) risk factors, such as hypertension, diabetes and metabolic syndrome (MS); however, whether higher UA is independently associated with CKD is still debatable. Other studies found that low UA level may reflect inadequate protection against oxidant-mediated stress; it is also unknown whether hypouricemia may have a harmful effect on the kidney. No studies have examined whether there is a J-shaped relationship between UA and incident CKD.

Methods: The association between UA and incident kidney disease (Glomerular filtration rate <60 mL/min per 1.73 m(2)) was examined among 94 422 Taiwanese participants, aged >= 20 years with a mean 3.5 years follow-up in a retrospective cohort. The association between UA and CKD was evaluated using Cox models with adjustment for confounders.

Results: The adjusted hazard ratio (HR) for incident CKD was 1.03 (95% confidence interval (CI), 1.01 to 1.06) for baseline UA level (increase by 1 mg/dL). Compared with serum UA in the first quintile (2.0 to 4.5 mg/dL), the multivariate-adjusted HR for CKD of the fifth (>= 7.3 mg/dL), fourth (6.3 to 7.2 mg/dL), third (5.5 to 6.2 mg/dL), second (4.6 to 5.4 mg/dL) and hyopuricemia (<2.0 mg/dL) were 1.15 (95% CI, 1.01-1.30), 0.98 (95% CI, 0.87-1.10), 1.06 (95% CI, 0.94-1.19), 1.02 (95% CI, 0.91-1.14) and 1.65(95% CI, 0.53-5.15), respectively. The tests for the non-linear association were all not significant for both male and female. Gender-specific model revealed only the UA above 7.3 mg/dL with the increased risk of new-onset CKD in males.

Conclusion: Hyperuricemia is a risk factor for CKD in Taiwan, future studies are still necessary to determine whether hypouricemia increases the risk of CKD.

语种: 英语
WOS记录号: WOS:000297414300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55947
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Shengfeng,Shu, Zheng,Tao, Qiushan,et al. Uric acid and incident chronic kidney disease in a large health check-up population in Taiwan[J]. NEPHROLOGY,2011,16(8):767-776.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Shengfeng]'s Articles
[Shu, Zheng]'s Articles
[Tao, Qiushan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Shengfeng]‘s Articles
[Shu, Zheng]‘s Articles
[Tao, Qiushan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace