学科主题 | 基础医学 |
Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups | |
Wang, Yuanyuan1; Tong, Jia1; Li, Shuping1; Zhang, Ran1; Chen, Li1; Wang, Yuhui2; Zheng, Min3; Wang, Meili3; Liu, George2; Dai, Yunping3; Zhao, Yaofeng1; Li, Ning1 | |
刊名 | PLOS ONE
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2011-06-17 | |
DOI | 10.1371/journal.pone.0020895 |
卷 | 6期:6 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Multidisciplinary Sciences |
资助者 | National S & ; T Major Project ; National S & ; T Major Project |
研究领域[WOS] | Science & Technology - Other Topics |
关键词[WOS] | MUSCLE-SPECIFIC OVEREXPRESSION ; TRANSGENIC MICE ; DENSITY-LIPOPROTEIN ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; LACTATING RATS ; FATTY-ACIDS ; GOAT MILK ; PLASMA ; MORTALITY |
英文摘要 | Background: The mammary gland is a conserved site of lipoprotein lipase expression across species and lipoprotein lipase attachment to the luminal surface of mammary gland vascular endothelial cells has been implicated in the direction of circulating triglycerides into milk synthesis during lactation. Principal Findings: Here we report generation of transgenic mice harboring a human lipoprotein lipase gene driven by a mammary gland-specific promoter. Lipoprotein lipase levels in transgenic milk was raised to 0.16 mg/ml, corresponding to an activity of 8772.95 mU/ml. High lipoprotein lipase activity led to a significant reduction of triglyceride concentration in milk, but other components were largely unchanged. Normal pups fed with transgenic milk showed inferior growth performances compared to those fed with normal milk. Conclusion: Our study suggests a possibility to reduce the triglyceride content of cow milk using transgenic technology. |
语种 | 英语 |
所属项目编号 | 2009ZX08007-001B |
资助者 | National S & ; T Major Project ; National S & ; T Major Project |
WOS记录号 | WOS:000291737600029 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/55951 |
Collection | 北京大学基础医学院_心血管所 |
作者单位 | 1.GenProt Biotech Ltd, Beijing, Peoples R China 2.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China 3.Peking Univ, Inst Cardiovasc Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China |
Recommended Citation GB/T 7714 | Wang, Yuanyuan,Tong, Jia,Li, Shuping,et al. Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups[J]. PLOS ONE,2011,6(6). |
APA | Wang, Yuanyuan.,Tong, Jia.,Li, Shuping.,Zhang, Ran.,Chen, Li.,...&Li, Ning.(2011).Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups.PLOS ONE,6(6). |
MLA | Wang, Yuanyuan,et al."Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups".PLOS ONE 6.6(2011). |
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