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学科主题基础医学
Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups
Wang, Yuanyuan1; Tong, Jia1; Li, Shuping1; Zhang, Ran1; Chen, Li1; Wang, Yuhui2; Zheng, Min3; Wang, Meili3; Liu, George2; Dai, Yunping3; Zhao, Yaofeng1; Li, Ning1
刊名PLOS ONE
2011-06-17
DOI10.1371/journal.pone.0020895
6期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National S &amp ; T Major Project ; National S &amp ; T Major Project
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]MUSCLE-SPECIFIC OVEREXPRESSION ; TRANSGENIC MICE ; DENSITY-LIPOPROTEIN ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; LACTATING RATS ; FATTY-ACIDS ; GOAT MILK ; PLASMA ; MORTALITY
英文摘要

Background: The mammary gland is a conserved site of lipoprotein lipase expression across species and lipoprotein lipase attachment to the luminal surface of mammary gland vascular endothelial cells has been implicated in the direction of circulating triglycerides into milk synthesis during lactation.

Principal Findings: Here we report generation of transgenic mice harboring a human lipoprotein lipase gene driven by a mammary gland-specific promoter. Lipoprotein lipase levels in transgenic milk was raised to 0.16 mg/ml, corresponding to an activity of 8772.95 mU/ml. High lipoprotein lipase activity led to a significant reduction of triglyceride concentration in milk, but other components were largely unchanged. Normal pups fed with transgenic milk showed inferior growth performances compared to those fed with normal milk.

Conclusion: Our study suggests a possibility to reduce the triglyceride content of cow milk using transgenic technology.

语种英语
所属项目编号2009ZX08007-001B
资助者National S &amp ; T Major Project ; National S &amp ; T Major Project
WOS记录号WOS:000291737600029
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55951
Collection北京大学基础医学院_心血管所
作者单位1.GenProt Biotech Ltd, Beijing, Peoples R China
2.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China
3.Peking Univ, Inst Cardiovasc Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yuanyuan,Tong, Jia,Li, Shuping,et al. Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups[J]. PLOS ONE,2011,6(6).
APA Wang, Yuanyuan.,Tong, Jia.,Li, Shuping.,Zhang, Ran.,Chen, Li.,...&Li, Ning.(2011).Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups.PLOS ONE,6(6).
MLA Wang, Yuanyuan,et al."Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups".PLOS ONE 6.6(2011).
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