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学科主题: 基础医学
题名:
Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups
作者: Wang, Yuanyuan1; Tong, Jia1; Li, Shuping1; Zhang, Ran1; Chen, Li1; Wang, Yuhui2; Zheng, Min3; Wang, Meili3; Liu, George2; Dai, Yunping3; Zhao, Yaofeng1; Li, Ning1
刊名: PLOS ONE
发表日期: 2011-06-17
DOI: 10.1371/journal.pone.0020895
卷: 6, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MUSCLE-SPECIFIC OVEREXPRESSION ; TRANSGENIC MICE ; DENSITY-LIPOPROTEIN ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; LACTATING RATS ; FATTY-ACIDS ; GOAT MILK ; PLASMA ; MORTALITY
英文摘要:

Background: The mammary gland is a conserved site of lipoprotein lipase expression across species and lipoprotein lipase attachment to the luminal surface of mammary gland vascular endothelial cells has been implicated in the direction of circulating triglycerides into milk synthesis during lactation.

Principal Findings: Here we report generation of transgenic mice harboring a human lipoprotein lipase gene driven by a mammary gland-specific promoter. Lipoprotein lipase levels in transgenic milk was raised to 0.16 mg/ml, corresponding to an activity of 8772.95 mU/ml. High lipoprotein lipase activity led to a significant reduction of triglyceride concentration in milk, but other components were largely unchanged. Normal pups fed with transgenic milk showed inferior growth performances compared to those fed with normal milk.

Conclusion: Our study suggests a possibility to reduce the triglyceride content of cow milk using transgenic technology.

语种: 英语
所属项目编号: 2009ZX08007-001B
项目资助者: National S &amp ; T Major Project
WOS记录号: WOS:000291737600029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55951
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.GenProt Biotech Ltd, Beijing, Peoples R China
2.China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing 100094, Peoples R China
3.Peking Univ, Inst Cardiovasc Sci, Hlth Sci Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Yuanyuan,Tong, Jia,Li, Shuping,et al. Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups[J]. PLOS ONE,2011,6(6).
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