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学科主题: 临床医学
题名:
Detection of Testosterone, Dihydrotestosterone, Dehydroepiandrosterone in Emasculated Rat Prostate via GC/MRM
作者: Chen Jun1; Liang Qiong-Lin1; Li Hui2; Luo Guo-An1; Wang Yi-Ming1
关键词: Prostate ; Androgen ; Gas chromatography-Mass spectrometry
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2008-11-10
卷: 29, 期:11, 页:2155-2158
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; ANABOLIC RESIDUES ; STEROIDS ; CANCER
英文摘要:

Prostate cancer is a common malignancy in men. For prostate dependent on androgen for growth, orchiectomy is adopted in clinical therapy along with medicines aimed to restrain the synthesis and secretion of androgens in adrenal. The function of adrenal androgen is not clear till now, therefore, it needs more consideration on how to operate the therapy properly. We established a GC/MRM method for the detection of androgens in tissue sample, by which we monitored the concentration of androgens in emasculated rat. It is shown that the influence of adrenal androgen on the hormone metabolism in prostate existed via tills experiment.

语种: 中文
WOS记录号: WOS:000261462700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55953
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
2.Peking Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China

Recommended Citation:
Chen Jun,Liang Qiong-Lin,Li Hui,et al. Detection of Testosterone, Dihydrotestosterone, Dehydroepiandrosterone in Emasculated Rat Prostate via GC/MRM[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(11):2155-2158.
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