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Fourier transform infrared spectroscopic investigation of human blood cells in bone marrow from AML and CML patients
Gao, TY; Ci, YX; Fu, S; Wang, DB
关键词Fourier Transform Infrared Spectroscopy Leukemia Blood Cells In Bone Marrow
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2001-06-01
22期:6页:908-911
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]FT-IR SPECTROSCOPY ; TISSUES
英文摘要

Eight samples of bone marrow coming from patients affected by acute myeloid leukemia (AML) and nine samples from patients suffered from chronic myeloid leukemia(CML) were studied by FTIR spectroscopy. Obvious differences are observed among the erythrocytes, granulocytes and lymphocytes, No significant differences are found in the granulocytes/lymphocytes between AML and CML samples whereas the spectroscopic differences of leukemic erythrocytes are observed, The ratios of the integrated areas of the band at 1 540 cm(-1) and 1 084 cm(-1) in the spectra of erythrocytes from AML are closer and lower than the corresponding ratios from CML samples. Compared to that of CML, the erythrocytes from AML show broader amide band I and have a higher percentage of alpha -helix in the secondary structures of proteins. These differences indicate the different contributions of red cells in erythrocytic series in the erythropoietic development from proerythroblast to the matured erythrocytes, The results imply the maturation of red cells in bone marrow is related to the proliferation of leukemic cells. The noticeable differences may have important implications for analyzing and evaluating leukemia.

语种中文
WOS记录号WOS:000169605000009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55956
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Dept Chem, Beijing 100871, Peoples R China
2.Peking Univ, Coll Med, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Gao, TY,Ci, YX,Fu, S,et al. Fourier transform infrared spectroscopic investigation of human blood cells in bone marrow from AML and CML patients[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2001,22(6):908-911.
APA Gao, TY,Ci, YX,Fu, S,&Wang, DB.(2001).Fourier transform infrared spectroscopic investigation of human blood cells in bone marrow from AML and CML patients.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,22(6),908-911.
MLA Gao, TY,et al."Fourier transform infrared spectroscopic investigation of human blood cells in bone marrow from AML and CML patients".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 22.6(2001):908-911.
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