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Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer
Tian, Xiaodong; Hao, Kun; Qin, Changfu; Xie, Kun; Xie, Xuehai; Yang, Yinmo
关键词Chemosensitivity Gemcitabine Insulin-like Growth Factor 1 Receptor Pancreatic Cancer
刊名DIGESTIVE DISEASES AND SCIENCES
2013-09-01
DOI10.1007/s10620-013-2673-2
58期:9页:2705-2712
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ENHANCES CHEMOSENSITIVITY ; DOWN-REGULATION ; GEMCITABINE ; EXPRESSION ; CELLS ; SURVIVAL ; ANTIBODY ; THERAPY ; TUMORS
英文摘要

Background Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic cancer. However, the underlying mechanism remains unclear.

Aims The purpose of this study was to investigate the effects of IGF1R knockdown on the proliferation, apoptosis and chemosensitivity of pancreatic cancer cells, and explore the possible mechanisms.

Methods Pancreatic cancer cells expressing IGF1R shRNA were established, and the cell proliferation, colony formation, and chemosensitivity to gemcitabine were examined in vitro. The activation of AKT and NF-kappa B was detected by Western blot analysis and luciferase assay, respectively. Xenograft mice models were established to evaluate the in vivo anti-tumor effects of IGF1R knockdown.

Results IGF1R knockdown notably inhibited pancreatic cancer cell proliferation and colony formation, induced apoptosis, and inhibited xenograft tumor growth. Moreover, IGF1R knockdown significantly enhanced chemosensitivity to gemcitabine in pancreatic cancer cells, and this was correlated with the inhibition of PI3K/AKT and NF-kappa B pathways.

Conclusions IGF1R knockdown suppresses tumor growth and enhances chemosensitivity in pancreatic cancer via the inhibition of PI3K/AKT and NF-kappa B pathways, and is a promising approach to overcome the chemoresistance of pancreatic cancer.

语种英语
WOS记录号WOS:000324246300056
项目编号81172184 ; 7122188
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; China Scholarship Council, Beijing, China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55961
专题北京大学第一临床医学院_普通外科
作者单位Peking Univ, Dept Gen Surg, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Tian, Xiaodong,Hao, Kun,Qin, Changfu,et al. Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer[J]. DIGESTIVE DISEASES AND SCIENCES,2013,58(9):2705-2712.
APA Tian, Xiaodong,Hao, Kun,Qin, Changfu,Xie, Kun,Xie, Xuehai,&Yang, Yinmo.(2013).Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer.DIGESTIVE DISEASES AND SCIENCES,58(9),2705-2712.
MLA Tian, Xiaodong,et al."Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer".DIGESTIVE DISEASES AND SCIENCES 58.9(2013):2705-2712.
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