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学科主题: 临床医学
题名:
Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer
作者: Tian, Xiaodong; Hao, Kun; Qin, Changfu; Xie, Kun; Xie, Xuehai; Yang, Yinmo
关键词: Chemosensitivity ; Gemcitabine ; Insulin-like growth factor 1 receptor ; Pancreatic cancer
刊名: DIGESTIVE DISEASES AND SCIENCES
发表日期: 2013-09-01
DOI: 10.1007/s10620-013-2673-2
卷: 58, 期:9, 页:2705-2712
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ENHANCES CHEMOSENSITIVITY ; DOWN-REGULATION ; GEMCITABINE ; EXPRESSION ; CELLS ; SURVIVAL ; ANTIBODY ; THERAPY ; TUMORS
英文摘要:

Background Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic cancer. However, the underlying mechanism remains unclear.

Aims The purpose of this study was to investigate the effects of IGF1R knockdown on the proliferation, apoptosis and chemosensitivity of pancreatic cancer cells, and explore the possible mechanisms.

Methods Pancreatic cancer cells expressing IGF1R shRNA were established, and the cell proliferation, colony formation, and chemosensitivity to gemcitabine were examined in vitro. The activation of AKT and NF-kappa B was detected by Western blot analysis and luciferase assay, respectively. Xenograft mice models were established to evaluate the in vivo anti-tumor effects of IGF1R knockdown.

Results IGF1R knockdown notably inhibited pancreatic cancer cell proliferation and colony formation, induced apoptosis, and inhibited xenograft tumor growth. Moreover, IGF1R knockdown significantly enhanced chemosensitivity to gemcitabine in pancreatic cancer cells, and this was correlated with the inhibition of PI3K/AKT and NF-kappa B pathways.

Conclusions IGF1R knockdown suppresses tumor growth and enhances chemosensitivity in pancreatic cancer via the inhibition of PI3K/AKT and NF-kappa B pathways, and is a promising approach to overcome the chemoresistance of pancreatic cancer.

语种: 英语
所属项目编号: 81172184 ; 7122188
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; China Scholarship Council, Beijing, China
WOS记录号: WOS:000324246300056
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55961
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Dept Gen Surg, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Tian, Xiaodong,Hao, Kun,Qin, Changfu,et al. Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer[J]. DIGESTIVE DISEASES AND SCIENCES,2013,58(9):2705-2712.
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