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学科主题: 临床医学
题名:
The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy
作者: Jia, Xiao-yu1,2,3,4; Hu, Shui-yi1,2,3,4; Chen, Jun-liang1,2,3,4; Qu, Zhen1,2,3,4; Liu, Gang1,2,3,4; Cui, Zhao1,2,3,4; Zhao, Ming-hui1,2,3,4,5
关键词: anti-GBM antibodies ; antigen ; epitope ; IgG subclasses ; membranous nephropathy ; M-type phospholipase A(2) receptor
刊名: KIDNEY INTERNATIONAL
发表日期: 2014-04-01
DOI: 10.1038/ki.2013.364
卷: 85, 期:4, 页:945-952
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GOODPASTURES-SYNDROME ; ANTI-GBM ; ALPHA-3(IV) COLLAGEN ; MEDIATED GLOMERULONEPHRITIS ; IMMUNE-COMPLEXES ; RENAL DAMAGE ; NC1 DOMAIN ; AUTOANTIBODIES ; IV ; IDENTIFICATION
英文摘要:

The association of anti-glomerular basement membrane (GBM) disease, also known as Goodpasture′s disease, with membranous nephropathy (MN) has been well documented. However, little is known about the clinical and immunological features of patients with such a combination. This study was designed to investigate the clinical and immunological features of anti-GBM patients with MN and to provide insight into the pathogenesis of this rare entity. Eight patients with combined anti-GBM disease and MN were found to have significantly lower levels of serum creatinine, a significantly lower proportion of oliguria/anuria, and significantly better renal outcomes compared with 30 patients with classical anti-GBM disease. Antibody levels against the E-B conformational epitope of anti-alpha 3(IV) NC1 were significantly lower in these patients, as was their levels of anti-alpha 3(IV) NC1 immunoglobulin G1 (IgG1) and IgG3. Serum antibodies against the M-type phospholipase A(2) receptor were undetectable in anti-GBM patients with MN but presented in 13 of the 20 patients with primary MN. Thus, patients with combined anti-GBM disease and MN have distinct clinical features and a different immunological profile of MN.

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81170645
项目资助者: Chinese 973 Project ; Natural Science Fund of China ; National Natural Science Fund of China
WOS记录号: WOS:000333746200028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55963
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Jia, Xiao-yu,Hu, Shui-yi,Chen, Jun-liang,et al. The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy[J]. KIDNEY INTERNATIONAL,2014,85(4):945-952.
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