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The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy
Jia, Xiao-yu1,2,3,4; Hu, Shui-yi1,2,3,4; Chen, Jun-liang1,2,3,4; Qu, Zhen1,2,3,4; Liu, Gang1,2,3,4; Cui, Zhao1,2,3,4; Zhao, Ming-hui1,2,3,4,5
关键词Anti-gbm Antibodies Antigen Epitope Igg Subclasses Membranous Nephropathy M-type Phospholipase a(2) Receptor
刊名KIDNEY INTERNATIONAL
2014-04-01
DOI10.1038/ki.2013.364
85期:4页:945-952
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GOODPASTURES-SYNDROME ; ANTI-GBM ; ALPHA-3(IV) COLLAGEN ; MEDIATED GLOMERULONEPHRITIS ; IMMUNE-COMPLEXES ; RENAL DAMAGE ; NC1 DOMAIN ; AUTOANTIBODIES ; IV ; IDENTIFICATION
英文摘要

The association of anti-glomerular basement membrane (GBM) disease, also known as Goodpasture′s disease, with membranous nephropathy (MN) has been well documented. However, little is known about the clinical and immunological features of patients with such a combination. This study was designed to investigate the clinical and immunological features of anti-GBM patients with MN and to provide insight into the pathogenesis of this rare entity. Eight patients with combined anti-GBM disease and MN were found to have significantly lower levels of serum creatinine, a significantly lower proportion of oliguria/anuria, and significantly better renal outcomes compared with 30 patients with classical anti-GBM disease. Antibody levels against the E-B conformational epitope of anti-alpha 3(IV) NC1 were significantly lower in these patients, as was their levels of anti-alpha 3(IV) NC1 immunoglobulin G1 (IgG1) and IgG3. Serum antibodies against the M-type phospholipase A(2) receptor were undetectable in anti-GBM patients with MN but presented in 13 of the 20 patients with primary MN. Thus, patients with combined anti-GBM disease and MN have distinct clinical features and a different immunological profile of MN.

语种英语
WOS记录号WOS:000333746200028
项目编号2012CB517702 ; 81021004 ; 81170645
资助机构Chinese 973 Project ; Natural Science Fund of China ; National Natural Science Fund of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55963
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Jia, Xiao-yu,Hu, Shui-yi,Chen, Jun-liang,et al. The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy[J]. KIDNEY INTERNATIONAL,2014,85(4):945-952.
APA Jia, Xiao-yu.,Hu, Shui-yi.,Chen, Jun-liang.,Qu, Zhen.,Liu, Gang.,...&Zhao, Ming-hui.(2014).The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy.KIDNEY INTERNATIONAL,85(4),945-952.
MLA Jia, Xiao-yu,et al."The clinical and immunological features of patients with combined anti-glomerular basement membrane disease and membranous nephropathy".KIDNEY INTERNATIONAL 85.4(2014):945-952.
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