北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Construction of the A ring of halichomycin via a RCM strategy
作者: Mao, Shiyong; Jia, Yanxing
关键词: Halichomycin ; Total synthesis ; Natural product ; Ring-closing metathesis (RCM)
刊名: TETRAHEDRON LETTERS
发表日期: 2013-08-07
DOI: 10.1016/j.tetlet.2013.06.027
卷: 54, 期:32, 页:4343-4345
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: OLEFIN-METATHESIS CATALYSTS ; CLOSING METATHESIS ; STEREOSELECTIVE PREPARATION ; ASYMMETRIC-SYNTHESIS ; NATURAL-PRODUCTS ; FRAGMENT ; MACROCYCLIZATION ; PLECOMACROLIDES ; NARBONOLIDE ; COMPLEXES
英文摘要:

Attempts to the synthesis of the A ring of halichomycin via ring-closing metathesis (RCM) reaction were investigated. When triene 5 was used as the precursor of cyclization, only unexpected byproduct aldehyde 17 was obtained. When diene 6 was used as the precursor of cyclization, the desired product 20 was obtained in reasonable yield. This work demonstrated that both modification of the substrate and the RCM reaction conditions are important for obtaining the desired 11-membered macrocycle in reasonable yield. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21290180 ; 20972007 ; 2010CB833200 ; 20120001110100
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Ph.D. Programs Foundation of Ministry of Education of China
WOS记录号: WOS:000321802800053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55964
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Mao, Shiyong,Jia, Yanxing. Construction of the A ring of halichomycin via a RCM strategy[J]. TETRAHEDRON LETTERS,2013,54(32):4343-4345.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mao, Shiyong]'s Articles
[Jia, Yanxing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mao, Shiyong]‘s Articles
[Jia, Yanxing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace