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Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission
Zhang, Yulin; Zeng, Hang; Liu, Peng; Liu, Lin; Xia, Junke; Wang, Lin; Zou, Qinghua; Wang, Ling; Zhuang, Hui
关键词Hepatitis e Virus Zoonotic Transmission Rabbits Hev 239 Vaccine Immunization Strategy
刊名VACCINE
2015-09-11
DOI10.1016/j.vaccine.2015.07.040
33期:38页:4922-4928
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Medicine, Research & Experimental
研究领域[WOS]Immunology ; Research & Experimental Medicine
关键词[WOS]E VIRUS-INFECTION ; ORGAN-TRANSPLANT RECIPIENTS ; CHRONIC LIVER-DISEASE ; WILD BOAR MEAT ; DEVELOPED-COUNTRIES ; UNITED-STATES ; BLOOD-DONORS ; FOOD-BORNE ; GENOTYPE ; CHINA
英文摘要

Hepatitis E virus (HEV) infection has become a significant global public health concern as increasing cases of acute and chronic hepatitis E are reported. HEV of animal origin was proved to be a possible source of human infection and a previous study showed that the recent licensed HEV 239 vaccine can serve as a candidate vaccine to manage animal sources of HEV infection. However, previous immunization strategy for rabbits was the same as that for human, which is too costly to conduct large-scale animal vaccination. In an effort to reduce the costs, three vaccination schemes were assessed in the present study. Forty specific pathogen-free (SPF) rabbits were divided randomly into five groups with eight animals for each and inoculated intramuscularly with different doses of HEV 239 and placebo, respectively. All animals were challenged intravenously with swine HEV-4 and rabbit HEV of different titers 7 weeks after the initial immunization and then fecal virus excretion was monitored for 10 weeks. The results indicated that immunizing rabbits with two 10 mu g doses of the vaccine is superior to vaccination with two 20 mu g doses or a single 30 mu g dose, which can protect rabbits against homologous and heterologous HEV infection. These findings could enable implementation of large-scale animal vaccination to prevent rabbit HEV infection and zoonotic transmission. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000361583100028
项目编号81271827 ; 20120001110098
资助机构National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55968
专题北京大学基础医学院
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol & Infect Dis Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yulin,Zeng, Hang,Liu, Peng,et al. Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission[J]. VACCINE,2015,33(38):4922-4928.
APA Zhang, Yulin.,Zeng, Hang.,Liu, Peng.,Liu, Lin.,Xia, Junke.,...&Zhuang, Hui.(2015).Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission.VACCINE,33(38),4922-4928.
MLA Zhang, Yulin,et al."Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission".VACCINE 33.38(2015):4922-4928.
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