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Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure
Zou, Zhengsheng; Xu, Dongping; Li, Baosen; Xin, Shaojie; Zhang, Zheng; Huang, Lei2; Fu, Junliang; Yang, Yongping; Jin, Lei; Zhao, Jing-Min; Shi, Ming; Zhou, Guangde; Sun, Yanling; Wang, Fu-Sheng1
关键词Acute-on-chronic Liver Failure Hepatitis b Virus Immulogically Competent Cells Immunohistochemistry Liver-infiltrating Lymphocytes
刊名HEPATOLOGY RESEARCH
2009-12-01
DOI10.1111/j.1872-034X.2009.00571.x
39期:12页:1198-1207
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CHRONIC HEPATITIS-B ; TUMOR-NECROSIS-FACTOR ; T-CELLS ; PATHOPHYSIOLOGICAL BASIS ; INFECTION ; VIRUS ; PATHOGENESIS ; SURVIVAL ; HUMANS
英文摘要

Aims:

This study attempts to characterize the feature of immunologically competent cells (ICCs) and evaluate its clinical implication in patients with acute-on-chronic liver failure (ACLF) in relation to chronic hepatitis B virus (HBV) infection.

Methods:

Circulating ICCs were examined in ACLF patients (n = 75), as well as in patients with hepatitis B (CHB, n = 31), CHB-related liver cirrhosis (LC, n = 36), and normal controls (NC, n = 30). Intrahepatic ICCs in some patients were further analyzed via immunohistochemical and flow cytometric assays.

Results:

Total lymphocytes, CD4+ T cells, CD8+ T cells, and NK cells in circulation were numerically lower in the ACLF and LC groups compared to the CHB and NC groups. Importantly, the number of these cells was significantly lower in non-surviving ACLF patients compared with surviving ACLF patients. In comparison to NC, ACLF patients displayed a significantly higher ratio of liver-infiltrating CD4+ T-cell frequency than its circulating counterpart, suggesting that the possiblility of the ICCs compartmentalization from the peripheral blood into the liver in ACLF. Immunohistochemical analysis showed that intrahepatic CD4+ cells, CD8+ cells, and CD56+ cells were significantly higher in the ACLF group compared with the other three groups, suggesting a stronger cellular immune response-mediated inflammation in ACLF group than other patient groups.

Conclusions:

The abnormal prevalence of circulating and intrahepatic ICCs possibly acts as an important factor that may drive the progression of HBV-related ACLF.

语种英语
WOS记录号WOS:000272306100006
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55969
专题北京大学第二临床医学院_肝胆外科
作者单位1.Beijing Univ, Res Ctr Biol Therapy, Beijing Inst Infect Dis, Beijing 302 Hosp, Beijing 100039, Peoples R China
2.Beijing Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100039, Peoples R China
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GB/T 7714
Zou, Zhengsheng,Xu, Dongping,Li, Baosen,et al. Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure[J]. HEPATOLOGY RESEARCH,2009,39(12):1198-1207.
APA Zou, Zhengsheng.,Xu, Dongping.,Li, Baosen.,Xin, Shaojie.,Zhang, Zheng.,...&Wang, Fu-Sheng.(2009).Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure.HEPATOLOGY RESEARCH,39(12),1198-1207.
MLA Zou, Zhengsheng,et al."Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure".HEPATOLOGY RESEARCH 39.12(2009):1198-1207.
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