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学科主题: 临床医学
题名:
HIP-55 negatively regulates myocardial contractility at the single-cell level
作者: Xing, Rui1,2; Li, Shanshan3; Liu, Kai3; Yuan, Yuan4; Li, Qing4; Deng, Hao4; Yang, Chengzhi1,2; Huang, Jianyong4; Zhang, Youyi1,2,3; Fang, Jing3,4; Xiong, Chunyang3,4; Li, Zijian1,2
关键词: HIP-55 ; Myocardial contractility ; Traction force microscopy
刊名: JOURNAL OF BIOMECHANICS
发表日期: 2014-08-22
DOI: 10.1016/j.jbiomech.2014.05.003
卷: 47, 期:11, 页:2715-2720
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Engineering, Biomedical
研究领域[WOS]: Biophysics ; Engineering
关键词[WOS]: HEART-FAILURE ; ADAPTER PROTEIN ; MAMMALIAN ABP1 ; DIFFERENTIATION ; CYTOSKELETON ; HYPERTROPHY ; RECEPTORS ; FORCE
英文摘要:

Myocardial contractility is crucial for cardiac output and heart function. But the detailed mechanisms of regulation remain unclear. In the present study, we found that HIP-55, an actin binding protein, negatively regulates myocardial contractility at the single-cell level. HIP-55 was overexpressed and knocked down in cardiomyocytes with an adenovirus infection. The traction forces exerted by single cardiomyocyte were measured using cell traction force microscopy. The results showed that HIP-55 knockdown significantly increased the contractility of the cardiomyocytes and HIP-55 overexpression could markedly reverse this process. Furthermore, HIP-55 was obviously co-localized with F-actin in cardiomyocytes, suggesting that HIP-55 regulated cardiac contractile function through the interaction between HIP-55 and F-actin. This study reveals the regulatory mechanisms of myocardial contractility and provides a new target for preventing and treating cardiovascular disease. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2013CB933702 ; 2011CB503903 ; 81270157 ; 11272015 ; 11072004 ; 81070078 ; 81030001 ; 7102158
项目资助者: Major State Basic Research Development Program of China (973 Program) ; National Natural Science Foundation of China ; Beijing Natural Science Foundation of China
WOS记录号: WOS:000341462900027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55973
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China
2.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
3.Peking Univ, Inst Vasc Med, Hosp 3,Minist Hlth,Key Lab Mol Cardiovasc Sci,Min, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100871, Peoples R China
4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

Recommended Citation:
Xing, Rui,Li, Shanshan,Liu, Kai,et al. HIP-55 negatively regulates myocardial contractility at the single-cell level[J]. JOURNAL OF BIOMECHANICS,2014,47(11):2715-2720.
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