IR@PKUHSC  > 北京大学第三临床医学院  > 检验科
学科主题临床医学
Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia
Bo Shi-ning1; Bo Jian3; Ning Yong-zhong2; Zhao Yu3; Lu Xiao-lin3; Yang Ji-yong4; Zhu Xi1; Yao Gai-qi1
关键词Escherichia Coli Bacteremia Hospital Mortality
刊名CHINESE MEDICAL JOURNAL
2011-02-05
DOI10.3760/cma.j.issn.0366-6999.2011.03.002
124期:3页:330-334
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CATHETER-RELATED BACTEREMIA ; INFECTION ; EPIDEMIOLOGY ; SURVEILLANCE ; PNEUMONIAE ; PROGNOSIS
英文摘要

Background Previous studies indicated that the time to positivity (TTP) of blood culture is a parameter correlating with degree of the bacteremia and outcome in patients with bloodstream infections caused by Escherichia coli (E. cob). The objective of this study was to further investigate the diagnostic and prognostic power of using UP to predict E. coli bacteremia.

Methods A retrospective cohort study at two university hospitals was conducted. We retrieved all the medical records of those with E. coli bloodstream infection according to the records generated by their microbiology departments. Univariate and multivariate analyses were applied to identify clinical factors correlating with fast bacterial growth and significant prognostic factors for hospital mortality.

Results Medical records of 353 episodes of E. coli bacteremia diagnosed between January 1, 2007 and December 31, 2009 were retrieved in the investigation. Univariate analysis demonstrated that the UP hours group is associated with higher incidence of active malignancies (41.7% vs. 27.2%, P=0.010), neutropenia (30% vs.14.3%, P=0.007), primary bacteremia (55.0% vs. 33.4%, P=0.002), and poorer outcome (hospital mortality 43.3% vs.11.9 /0, P=0.000) than the UP > 7 hours group. Multivariate analysis revealed that the significant predictors of hospital mortality, in rank order from high to low, were TTP (for TTP <= 7 hours, odds ratio (OR): 4.886; 95% confidence interval (Cl): 2.572-9.283; P=0.000), neutropenia (OR: 2.800; 95% Cl: 1.428-5.490; P=0.003), comedication of steroids or immunosuppressive agents (OR: 2.670; 95% Cl: 0.971-7.342; P=0.057).

Conclusions Incidence of malignancies, neutropenia and primary bacteremia correlates with fast bacterial growth in patients with E. coli bacteremia. The parameter of UP has been identified as a variable of highest correlation to hospital mortality and therefore can be potentially utilized as a mortality prognostic marker. Chin Med J 2011;124(3):330-334

语种英语
WOS记录号WOS:000287992400002
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55978
专题北京大学第三临床医学院_检验科
北京大学第三临床医学院_危重医学科
作者单位1.Peking Univ, Hosp 3, Dept Intens Care Unit, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Microbiol, Beijing 100083, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing 100853, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Microbiol, Beijing 100853, Peoples R China
推荐引用方式
GB/T 7714
Bo Shi-ning,Bo Jian,Ning Yong-zhong,et al. Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia[J]. CHINESE MEDICAL JOURNAL,2011,124(3):330-334.
APA Bo Shi-ning.,Bo Jian.,Ning Yong-zhong.,Zhao Yu.,Lu Xiao-lin.,...&Yao Gai-qi.(2011).Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia.CHINESE MEDICAL JOURNAL,124(3),330-334.
MLA Bo Shi-ning,et al."Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia".CHINESE MEDICAL JOURNAL 124.3(2011):330-334.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Bo Shi-ning]的文章
[Bo Jian]的文章
[Ning Yong-zhong]的文章
百度学术
百度学术中相似的文章
[Bo Shi-ning]的文章
[Bo Jian]的文章
[Ning Yong-zhong]的文章
必应学术
必应学术中相似的文章
[Bo Shi-ning]的文章
[Bo Jian]的文章
[Ning Yong-zhong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。