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学科主题: 临床医学
题名:
Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia
作者: Bo Shi-ning1; Bo Jian3; Ning Yong-zhong2; Zhao Yu3; Lu Xiao-lin3; Yang Ji-yong4; Zhu Xi1; Yao Gai-qi1
关键词: Escherichia coli ; bacteremia ; hospital mortality
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-02-05
DOI: 10.3760/cma.j.issn.0366-6999.2011.03.002
卷: 124, 期:3, 页:330-334
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CATHETER-RELATED BACTEREMIA ; INFECTION ; EPIDEMIOLOGY ; SURVEILLANCE ; PNEUMONIAE ; PROGNOSIS
英文摘要:

Background Previous studies indicated that the time to positivity (TTP) of blood culture is a parameter correlating with degree of the bacteremia and outcome in patients with bloodstream infections caused by Escherichia coli (E. cob). The objective of this study was to further investigate the diagnostic and prognostic power of using UP to predict E. coli bacteremia.

Methods A retrospective cohort study at two university hospitals was conducted. We retrieved all the medical records of those with E. coli bloodstream infection according to the records generated by their microbiology departments. Univariate and multivariate analyses were applied to identify clinical factors correlating with fast bacterial growth and significant prognostic factors for hospital mortality.

Results Medical records of 353 episodes of E. coli bacteremia diagnosed between January 1, 2007 and December 31, 2009 were retrieved in the investigation. Univariate analysis demonstrated that the UP hours group is associated with higher incidence of active malignancies (41.7% vs. 27.2%, P=0.010), neutropenia (30% vs.14.3%, P=0.007), primary bacteremia (55.0% vs. 33.4%, P=0.002), and poorer outcome (hospital mortality 43.3% vs.11.9 /0, P=0.000) than the UP > 7 hours group. Multivariate analysis revealed that the significant predictors of hospital mortality, in rank order from high to low, were TTP (for TTP <= 7 hours, odds ratio (OR): 4.886; 95% confidence interval (Cl): 2.572-9.283; P=0.000), neutropenia (OR: 2.800; 95% Cl: 1.428-5.490; P=0.003), comedication of steroids or immunosuppressive agents (OR: 2.670; 95% Cl: 0.971-7.342; P=0.057).

Conclusions Incidence of malignancies, neutropenia and primary bacteremia correlates with fast bacterial growth in patients with E. coli bacteremia. The parameter of UP has been identified as a variable of highest correlation to hospital mortality and therefore can be potentially utilized as a mortality prognostic marker. Chin Med J 2011;124(3):330-334

语种: 英语
WOS记录号: WOS:000287992400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55978
Appears in Collections:北京大学第三临床医学院_危重医学科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Intens Care Unit, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Microbiol, Beijing 100083, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Hematol, Beijing 100853, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Microbiol, Beijing 100853, Peoples R China

Recommended Citation:
Bo Shi-ning,Bo Jian,Ning Yong-zhong,et al. Relationship between time to positivity of blood culture with clinical characteristics and hospital mortality in patients with Escherichia coli bacteremia[J]. CHINESE MEDICAL JOURNAL,2011,124(3):330-334.
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