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学科主题: 临床医学
题名:
Derining peritoneal dialysis adequacy: Kt/Vurea revisited
作者: Zhe, Xing-Wei; Shan, Yi-Sheng; Cheng, Lei; Tian, Xin-Kui; Wang, Tao
关键词: peritoneal dialysis ; adequacy ; Kt/Vurea ; nitrogen balance
刊名: RENAL FAILURE
发表日期: 2007
DOI: 10.1080/08860220601166586
卷: 29, 期:3, 页:347-352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC-RENAL-FAILURE ; DOQI GUIDELINES ; CAPD PATIENTS ; PERMEABILITY ; NUTRITION ; REMOVAL ; PROTEIN ; SIMULATIONS ; TRANSPORT ; MEMBRANES
英文摘要:

Background. Although adequate peritoneal dialysis is not well defined, Kt(Vurea has been used as an index, and various values have been proposed. However, conflicting evidence existed regarding the appropriateness of using Kt/Vurea to define dialysis adequacy and its optimal value. Therefore, the present study performed a theoretical analysis on whether we should use Kt/Vurea to define peritoneal dialysis adequacy and what the optimal value should be. Methods. The three-pore model was applied to evaluate the transport patterns of different molecular weight solutes and fluid. Optimal Kt/Vurea value was estimated based on urea kinetics and nitrogen balance. Results. The removal pattern of small solute, middle and large molecules, and fluid and sodium are quite different. Depending on the dwell time, higher urea removal does not necessarily mean higher sodium, fluid, and other molecular weight solute removals. To reach nitrogen balance, the dialysis doses and therefore Kt/Vurea values varied with different dietary protein intakes in a patient with a given weight and residual renal function. Conclusion. This study shows that Kt/Vurea in peritoneal dialysis cannot represent the removal of other solutes and fluid, indicating that Kt/Vurea alone should not be used as a sole indicator of ′Peritoneal dialysis adequacy. The results also show that optimal Kt/Vurea cannot be a fixed value, but varies according to individual dietary protein intake and tolerable blood urea level.

语种: 英语
WOS记录号: WOS:000246884800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55979
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China

Recommended Citation:
Zhe, Xing-Wei,Shan, Yi-Sheng,Cheng, Lei,et al. Derining peritoneal dialysis adequacy: Kt/Vurea revisited[J]. RENAL FAILURE,2007,29(3):347-352.
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