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学科主题临床医学
Derining peritoneal dialysis adequacy: Kt/Vurea revisited
Zhe, Xing-Wei; Shan, Yi-Sheng; Cheng, Lei; Tian, Xin-Kui; Wang, Tao
关键词Peritoneal Dialysis Adequacy Kt/vurea Nitrogen Balance
刊名RENAL FAILURE
2007
DOI10.1080/08860220601166586
29期:3页:347-352
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHRONIC-RENAL-FAILURE ; DOQI GUIDELINES ; CAPD PATIENTS ; PERMEABILITY ; NUTRITION ; REMOVAL ; PROTEIN ; SIMULATIONS ; TRANSPORT ; MEMBRANES
英文摘要

Background. Although adequate peritoneal dialysis is not well defined, Kt(Vurea has been used as an index, and various values have been proposed. However, conflicting evidence existed regarding the appropriateness of using Kt/Vurea to define dialysis adequacy and its optimal value. Therefore, the present study performed a theoretical analysis on whether we should use Kt/Vurea to define peritoneal dialysis adequacy and what the optimal value should be. Methods. The three-pore model was applied to evaluate the transport patterns of different molecular weight solutes and fluid. Optimal Kt/Vurea value was estimated based on urea kinetics and nitrogen balance. Results. The removal pattern of small solute, middle and large molecules, and fluid and sodium are quite different. Depending on the dwell time, higher urea removal does not necessarily mean higher sodium, fluid, and other molecular weight solute removals. To reach nitrogen balance, the dialysis doses and therefore Kt/Vurea values varied with different dietary protein intakes in a patient with a given weight and residual renal function. Conclusion. This study shows that Kt/Vurea in peritoneal dialysis cannot represent the removal of other solutes and fluid, indicating that Kt/Vurea alone should not be used as a sole indicator of ′Peritoneal dialysis adequacy. The results also show that optimal Kt/Vurea cannot be a fixed value, but varies according to individual dietary protein intake and tolerable blood urea level.

语种英语
WOS记录号WOS:000246884800015
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55979
专题北京大学第三临床医学院_肾内科
作者单位Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhe, Xing-Wei,Shan, Yi-Sheng,Cheng, Lei,et al. Derining peritoneal dialysis adequacy: Kt/Vurea revisited[J]. RENAL FAILURE,2007,29(3):347-352.
APA Zhe, Xing-Wei,Shan, Yi-Sheng,Cheng, Lei,Tian, Xin-Kui,&Wang, Tao.(2007).Derining peritoneal dialysis adequacy: Kt/Vurea revisited.RENAL FAILURE,29(3),347-352.
MLA Zhe, Xing-Wei,et al."Derining peritoneal dialysis adequacy: Kt/Vurea revisited".RENAL FAILURE 29.3(2007):347-352.
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