IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines
Zhang, Xiaotian; Yashiro, Masakazu; Ren, Jun; Hirakawa, Kosei
关键词Histone Deacetylase Inhibitor Gastric Cancer Anticancer Drugs Chemosensitivity Apoptosis Cell Cycle Genes
刊名ONCOLOGY REPORTS
2006-09-01
16期:3页:563-568
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GENE-EXPRESSION ; DNA METHYLATION ; DOWN-REGULATION ; FOLINIC ACID ; CYCLE ARREST ; PHASE-II ; IN-VIVO ; APOPTOSIS ; P53 ; KINASE
英文摘要

Epigenetic alterations of the histone acetylation play an important role in the regulation of gene expression associated with cell cycles and apoptosis that may affect the chemosensitivity of gastric carcinomas. Recently, a histone deacetylase inhibitor, trichostatin A (TSA), was proven to be a chemo-sensitizer on human erythroleukemia cells. With the aim of improving the chemotherapeutic efficacy of gastric carcinoma, the effect of TSA on the chemosensitivity of several anticancer drugs in gastric carcinoma cells was investigated. Human gastric cancer cell lines, OCUM-8 and MKN-74, and 5 anticancer drugs, 5-fluorouracil (5-FU), paclitaxel (PTX), oxaliplatin (OXA), irinotecan (SN38) and gemcitabine (GEM) were used. In both gastric cancer cell lines, a synergistic anti-proliferative effect by the combination of TSA (30 ng/ml) with 5-FU, PTX or SN38 showed a synergistic anti-proliferative effect in OCUM-8 and MKN-74 cells. TSA increases the expression of p21, p53, DAPK-1 and the DAPK-2 gene in both OCUM-8 and MKN-74 cells. In conclusion, TSA is a promising chemotherapeutical agent in combination with anticancer drugs of 5-FU, PTX and SN38 in gastric cancer cell lines. The up-regulation of p53, p21, DAPK-1 and DAPK-2 might be associated with the synergistic effect of TSA.

语种英语
WOS记录号WOS:000239733300016
引用统计
被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55982
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Abeno Ku, Osaka 5458545, Japan
2.Peking Univ, Dept Med Oncol, Beijing Canc Hosp, Sch Oncol, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiaotian,Yashiro, Masakazu,Ren, Jun,et al. Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines[J]. ONCOLOGY REPORTS,2006,16(3):563-568.
APA Zhang, Xiaotian,Yashiro, Masakazu,Ren, Jun,&Hirakawa, Kosei.(2006).Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines.ONCOLOGY REPORTS,16(3),563-568.
MLA Zhang, Xiaotian,et al."Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines".ONCOLOGY REPORTS 16.3(2006):563-568.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Xiaotian]的文章
[Yashiro, Masakazu]的文章
[Ren, Jun]的文章
百度学术
百度学术中相似的文章
[Zhang, Xiaotian]的文章
[Yashiro, Masakazu]的文章
[Ren, Jun]的文章
必应学术
必应学术中相似的文章
[Zhang, Xiaotian]的文章
[Yashiro, Masakazu]的文章
[Ren, Jun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。