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学科主题: 临床医学
题名:
Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines
作者: Zhang, Xiaotian; Yashiro, Masakazu; Ren, Jun; Hirakawa, Kosei
关键词: histone deacetylase inhibitor ; gastric cancer ; anticancer drugs ; chemosensitivity ; apoptosis ; cell cycle ; genes
刊名: ONCOLOGY REPORTS
发表日期: 2006-09-01
卷: 16, 期:3, 页:563-568
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GENE-EXPRESSION ; DNA METHYLATION ; DOWN-REGULATION ; FOLINIC ACID ; CYCLE ARREST ; PHASE-II ; IN-VIVO ; APOPTOSIS ; P53 ; KINASE
英文摘要:

Epigenetic alterations of the histone acetylation play an important role in the regulation of gene expression associated with cell cycles and apoptosis that may affect the chemosensitivity of gastric carcinomas. Recently, a histone deacetylase inhibitor, trichostatin A (TSA), was proven to be a chemo-sensitizer on human erythroleukemia cells. With the aim of improving the chemotherapeutic efficacy of gastric carcinoma, the effect of TSA on the chemosensitivity of several anticancer drugs in gastric carcinoma cells was investigated. Human gastric cancer cell lines, OCUM-8 and MKN-74, and 5 anticancer drugs, 5-fluorouracil (5-FU), paclitaxel (PTX), oxaliplatin (OXA), irinotecan (SN38) and gemcitabine (GEM) were used. In both gastric cancer cell lines, a synergistic anti-proliferative effect by the combination of TSA (30 ng/ml) with 5-FU, PTX or SN38 showed a synergistic anti-proliferative effect in OCUM-8 and MKN-74 cells. TSA increases the expression of p21, p53, DAPK-1 and the DAPK-2 gene in both OCUM-8 and MKN-74 cells. In conclusion, TSA is a promising chemotherapeutical agent in combination with anticancer drugs of 5-FU, PTX and SN38 in gastric cancer cell lines. The up-regulation of p53, p21, DAPK-1 and DAPK-2 might be associated with the synergistic effect of TSA.

语种: 英语
WOS记录号: WOS:000239733300016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55982
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Abeno Ku, Osaka 5458545, Japan
2.Peking Univ, Dept Med Oncol, Beijing Canc Hosp, Sch Oncol, Beijing 100036, Peoples R China

Recommended Citation:
Zhang, Xiaotian,Yashiro, Masakazu,Ren, Jun,et al. Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines[J]. ONCOLOGY REPORTS,2006,16(3):563-568.
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