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Metabolites identification of bioactive licorice compounds in rats
Wang, Qi; Qian, Yi; Wang, Qing; Yang, Yan-fang; Ji, Shuai; Song, Wei; Qiao, Xue; Guo, De-an; Liang, Hong; Ye, Min
关键词Glycyrrhiza Uralensis Metabolites Identification Liquid Chromatography Coupled With Mass Spectrometry Saponin Flavonoid
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2015-11-10
DOI10.1016/j.jpba.2015.08.013
115期:0页:515-522
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]Tandem Mass-spectrometry ; Glycyrrhiza-uralensis ; Pharmacokinetics ; Flavonoids ; Coumarins
英文摘要

Licorice (Glycyrrhiza uralensis Fisch.) is one of the most popular herbal′medicines worldwide. This study aims to identify the metabolites of seven representative bioactive licorice compounds in rats. These compounds include 22 beta-acetoxyl glycyrrhizin (1), licoflavonol (2), licoricidin (3), licoisoflavanone (4), isoglycycoumarin (5), semilicoisoflavone B (6), and 3-methoxy-9-hydroxy-pterocarpan (7). After oral administration of 250 mg/kg of 1 or 40 mg/kg of 2-7 to rats, a total of 16, 43 and 31 metabolites were detected in the plasma, urine and fecal samples, respectively. The metabolites were characterized by HPLC/DAD/ESI-MSn and LC/IT-TOF-MS analyses. Particularly, two metabolites of 1 were unambiguously identified by comparing with reference standards, and 22 beta-acetoxyl glycyrrhizin-6 ′′-methyl ester (1-M2) is a new compound. Compound 1 could be readily hydrolyzed to eliminate the glucuronic acid residue. The phenolic compounds (4-7) mainly undertook phase II metabolism (glucuronidation or sulfation). Most phenolic compounds with an isoprenyl group (chain or cyclized, 2-5) could also undertake hydroxylation reaction. This is the first study on in vivo metabolism of these licorice compounds. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000363439500064
通讯作者邮箱lianghong@bjmu.edu.cn
项目编号81173644 ; 81222054 ; NCET-11-0019
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from Chinese Ministry of Education
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55987
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学第三临床医学院_护理部
北京大学精神卫生研究所_药房
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qi,Qian, Yi,Wang, Qing,et al. Metabolites identification of bioactive licorice compounds in rats[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015,115(0):515-522.
APA Wang, Qi.,Qian, Yi.,Wang, Qing.,Yang, Yan-fang.,Ji, Shuai.,...&Ye, Min.(2015).Metabolites identification of bioactive licorice compounds in rats.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,115(0),515-522.
MLA Wang, Qi,et al."Metabolites identification of bioactive licorice compounds in rats".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 115.0(2015):515-522.
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