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学科主题: 药学
题名:
Metabolites identification of bioactive licorice compounds in rats
作者: Wang, Qi; Qian, Yi; Wang, Qing; Yang, Yan-fang; Ji, Shuai; Song, Wei; Qiao, Xue; Guo, De-an; Liang, Hong; Ye, Min
关键词: Glycyrrhiza uralensis ; Metabolites identification ; Liquid chromatography coupled with mass spectrometry ; Saponin ; Flavonoid
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2015-11-10
DOI: 10.1016/j.jpba.2015.08.013
卷: 115, 页:515-522
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; GLYCYRRHIZA-URALENSIS ; PHARMACOKINETICS ; FLAVONOIDS ; COUMARINS
英文摘要:

Licorice (Glycyrrhiza uralensis Fisch.) is one of the most popular herbal′medicines worldwide. This study aims to identify the metabolites of seven representative bioactive licorice compounds in rats. These compounds include 22 beta-acetoxyl glycyrrhizin (1), licoflavonol (2), licoricidin (3), licoisoflavanone (4), isoglycycoumarin (5), semilicoisoflavone B (6), and 3-methoxy-9-hydroxy-pterocarpan (7). After oral administration of 250 mg/kg of 1 or 40 mg/kg of 2-7 to rats, a total of 16, 43 and 31 metabolites were detected in the plasma, urine and fecal samples, respectively. The metabolites were characterized by HPLC/DAD/ESI-MSn and LC/IT-TOF-MS analyses. Particularly, two metabolites of 1 were unambiguously identified by comparing with reference standards, and 22 beta-acetoxyl glycyrrhizin-6 ′′-methyl ester (1-M2) is a new compound. Compound 1 could be readily hydrolyzed to eliminate the glucuronic acid residue. The phenolic compounds (4-7) mainly undertook phase II metabolism (glucuronidation or sulfation). Most phenolic compounds with an isoprenyl group (chain or cyclized, 2-5) could also undertake hydroxylation reaction. This is the first study on in vivo metabolism of these licorice compounds. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81173644 ; 81222054 ; NCET-11-0019
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from Chinese Ministry of Education
WOS记录号: WOS:000363439500064
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55987
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Qi,Qian, Yi,Wang, Qing,et al. Metabolites identification of bioactive licorice compounds in rats[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015,115:515-522.
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