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学科主题: 临床医学
题名:
Effects of salvianolic acids on erythrocyte deformability in oleic acid induced acute lung injury in rabbits
作者: Xing, JJ; Chen, X; Tu, PF; Jiang, Y; Zhao, JY
关键词: acute lung injury ; salvianolic acids ; deformability ; malondialdehyde
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2006
卷: 34, 期:4, 页:507-517
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: RESPIRATORY-DISTRESS-SYNDROME ; BLOOD-CELL DEFORMABILITY ; SHEAR-FLOW FIELD ; LIPID-PEROXIDATION ; RBC DEFORMABILITY ; FREE-RADICALS ; TISSUE OXYGENATION ; OXIDATIVE STRESS ; LOW-VISCOSITY ; GUINEA-PIGS
英文摘要:

The present study was to investigate the protective effects of salvianolic acids (SA) on deformability of red blood cells (RBCs) and its mechanism during the development of acute lung injury (ALI) induced by oleic acid (OA) in rabbits. 32 rabbits were randomized into four groups, normal control group, OA-treated group (0.15 ml/kg), SA-treated group and OA+SA treated group. The blood samples were collected at 0, 10, 30, 60, 90, 120 and 180 min after OA injection. The RBC deformation index, Orientation index and small deformation index were measured by ektacytometry. The concentration of malondialdehyde (MDA) in RBCs was detected by the assay kit. Meanwhile, the pulmonary pathological examination and the blood gas analysis were also performed. The results showed that the deformation index, orientation index and small deformation index decreased during the early phase of ALI, while the concentration of MDA in RBCs increased during the course. Pre-treatment with SA increased the deformability and orientability of RBC significantly and decreased the concentration of MDA in RBCs compared with OA group. Meanwhile, the hypoxia and pulmonary pathological damage were much improved. These results suggest that there were erythrocyte deformability changes in the early phase of ALI. SA has the protective effects on erythrocyte deformability during the development of ALI induced by OA, which might be due to its antioxidant effect. These results are valid in rabbits and in a model of ARDS, it would be interesting to see the effects of SA in patients.

语种: 英语
WOS记录号: WOS:000237367700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55988
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Hemorheol Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
Xing, JJ,Chen, X,Tu, PF,et al. Effects of salvianolic acids on erythrocyte deformability in oleic acid induced acute lung injury in rabbits[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2006,34(4):507-517.
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