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学科主题: 临床医学
题名:
Electroacupuncture at PC6 or ST36 Influences the Effect of Tacrine on the Motility of Esophagus
作者: Wang, Chi; Chen, Xin; Xie, Peng-Yan
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2014
DOI: 10.1155/2014/263489
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: SPHINCTER RELAXATION
英文摘要:

Aim. To investigate the mechanisms of gastrointestinal side effects of tacrine, and find treatment methods with electroacupuncture (EA). Methods. Twenty-five healthy cats were randomly divided into 5 groups: gastric-distention group (model group), tacrine group (cholinesterase inhibitor), tacrine + sham acupoint group (control group), tacrine + PC6 (neiguan) group, and tacrine + ST36 (zusanli) group, with 5 cats in each group. Saline 2mL i.p. was given 30 min before gastric distention in model group. Tacrine 5.6mg/kg i.p. was given 30 minutes before gastric distention in the other groups. Tacrine + sham acupoint group (control group), tacrine + PC6 group, and tacrine + ST36 group received EA at corresponding acupoints during gastric distention. The frequency of TLESRs and LESP were recorded by using a perfused sleeve assembly. Results. Compared with the model group, tacrine significantly increased the frequency of gastric distention-induced TLESR (P < 0.05) but did not influence the rate of common cavity during TLESR. Tacrine significantly increased the LESP, which could not remain during gastric distention. EA at PC6 could decrease the frequency of TLESR and maintain the increase of LESP, but EA at ST36 did not have these effects. Conclusion. Tacrine can significantly increase the gastric distention-induced transient lower esophageal sphincter relaxations (TLESRs). Electroacupuncture (EA) at PC6 may reverse the above side effect.

语种: 英语
所属项目编号: 200800011077
项目资助者: Doctoral Program of Higher Education
WOS记录号: WOS:000334771700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55989
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Chi,Chen, Xin,Xie, Peng-Yan. Electroacupuncture at PC6 or ST36 Influences the Effect of Tacrine on the Motility of Esophagus[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014.
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