IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings
Zhao, Yan Li1; Tan, Shu Ping1; Yang, Fu De1; Wang, Li Li2; Feng, Wen Feng3; Chan, Raymond C. K.4,5; Gao, Xiao6; Zhou, Dong Feng7; Li, Bin Bin1; Song, Chong Sheng1; Fan, Feng Mei1; Tan, Yun Long1; Zhang, Jin Guo1; Wang, Yun Hui1; Zou, Yi Zhuang1
关键词Working Memory Schizophrenia Event-related Potentials Sternberg
刊名SCHIZOPHRENIA RESEARCH
2011-12-01
DOI10.1016/j.schres.2011.09.017
133期:1-3页:112-119
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]EVENT-RELATED POTENTIALS ; DORSOLATERAL PREFRONTAL CORTEX ; FMRI ; ACTIVATION ; DEFICIT ; ABNORMALITIES ; METAANALYSIS ; IMPAIRMENTS ; PERFORMANCE ; OBJECT
英文摘要

The present study combined a time-locked paradigm and high-time-resolution event-related potential (ERP) recordings to examine different phases of working memory, including early visual processing and late memory-related processes of encoding, maintenance, and retrieval, in 67 adults with schizophrenia and 46 healthy controls. Alterations in ERP components were correlated with task performance. Patients performed significantly worse in the working memory task than healthy subjects, although all subjects′ accuracy exceeded 80%. During encoding, the N1 and P2 component amplitudes were lower while the P300 amplitude was higher in schizophrenic patients compared to healthy controls. There were no differences between groups with respect to the mean amplitudes of the negative slow waves in the early stage (the first 400 ms) of the maintenance phase. However, in the next 500-ms time window, the patients exhibited a more negative deflection in the middle fronto-central region than the control group. Likewise, a similar pattern was observed in the second 500-ms period in the middle fronto-central region, although the effect was marginally significant. There were no differences between groups in the remaining 1000 ms. During retrieval, the P1, N1 and P2 amplitudes were lower while the P300 amplitude and latency were higher in schizophrenic patients. The present results indicate early visual deficits in the working memory task in adults with schizophrenia. Impairments in the maintenance phase were confined to the late rehearsal stage. The increased P300 amplitude at the fronto-central electrode sites along with the poorer behavioral performance suggests that schizophrenic patients have an inefficient working memory system. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000298512500018
项目编号D0906001040191 ; 7102086 ; 2007-3059 ; 2007id0301400101 ; D0906001000091
资助机构Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; Fund of Capital Medical Development and Research grant ; Beijing Municipal Training Programme Foundation for the Talents ; major project of Beijing science and technology
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55994
专题北京大学精神卫生研究所
作者单位1.Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Southwest Univ, Sch Psychol, Chongqing 400715, Peoples R China
7.Peking Univ, Inst Mental Hlth, Beijing 100091, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yan Li,Tan, Shu Ping,Yang, Fu De,et al. Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings[J]. SCHIZOPHRENIA RESEARCH,2011,133(1-3):112-119.
APA Zhao, Yan Li.,Tan, Shu Ping.,Yang, Fu De.,Wang, Li Li.,Feng, Wen Feng.,...&Zou, Yi Zhuang.(2011).Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings.SCHIZOPHRENIA RESEARCH,133(1-3),112-119.
MLA Zhao, Yan Li,et al."Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings".SCHIZOPHRENIA RESEARCH 133.1-3(2011):112-119.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Yan Li]的文章
[Tan, Shu Ping]的文章
[Yang, Fu De]的文章
百度学术
百度学术中相似的文章
[Zhao, Yan Li]的文章
[Tan, Shu Ping]的文章
[Yang, Fu De]的文章
必应学术
必应学术中相似的文章
[Zhao, Yan Li]的文章
[Tan, Shu Ping]的文章
[Yang, Fu De]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。