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学科主题: 精神卫生
题名:
Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings
作者: Zhao, Yan Li1; Tan, Shu Ping1; Yang, Fu De1; Wang, Li Li2; Feng, Wen Feng3; Chan, Raymond C. K.4,5; Gao, Xiao6; Zhou, Dong Feng7; Li, Bin Bin1; Song, Chong Sheng1; Fan, Feng Mei1; Tan, Yun Long1; Zhang, Jin Guo1; Wang, Yun Hui1; Zou, Yi Zhuang1
关键词: Working memory ; Schizophrenia ; Event-related potentials ; Sternberg
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2011-12-01
DOI: 10.1016/j.schres.2011.09.017
卷: 133, 期:1-3, 页:112-119
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: EVENT-RELATED POTENTIALS ; DORSOLATERAL PREFRONTAL CORTEX ; FMRI ; ACTIVATION ; DEFICIT ; ABNORMALITIES ; METAANALYSIS ; IMPAIRMENTS ; PERFORMANCE ; OBJECT
英文摘要:

The present study combined a time-locked paradigm and high-time-resolution event-related potential (ERP) recordings to examine different phases of working memory, including early visual processing and late memory-related processes of encoding, maintenance, and retrieval, in 67 adults with schizophrenia and 46 healthy controls. Alterations in ERP components were correlated with task performance. Patients performed significantly worse in the working memory task than healthy subjects, although all subjects′ accuracy exceeded 80%. During encoding, the N1 and P2 component amplitudes were lower while the P300 amplitude was higher in schizophrenic patients compared to healthy controls. There were no differences between groups with respect to the mean amplitudes of the negative slow waves in the early stage (the first 400 ms) of the maintenance phase. However, in the next 500-ms time window, the patients exhibited a more negative deflection in the middle fronto-central region than the control group. Likewise, a similar pattern was observed in the second 500-ms period in the middle fronto-central region, although the effect was marginally significant. There were no differences between groups in the remaining 1000 ms. During retrieval, the P1, N1 and P2 amplitudes were lower while the P300 amplitude and latency were higher in schizophrenic patients. The present results indicate early visual deficits in the working memory task in adults with schizophrenia. Impairments in the maintenance phase were confined to the late rehearsal stage. The increased P300 amplitude at the fronto-central electrode sites along with the poorer behavioral performance suggests that schizophrenic patients have an inefficient working memory system. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: D0906001040191 ; 7102086 ; 2007-3059 ; 2007id0301400101 ; D0906001000091
项目资助者: Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; Fund of Capital Medical Development and Research grant ; Beijing Municipal Training Programme Foundation for the Talents ; major project of Beijing science and technology
WOS记录号: WOS:000298512500018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55994
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Southwest Univ, Sch Psychol, Chongqing 400715, Peoples R China
7.Peking Univ, Inst Mental Hlth, Beijing 100091, Peoples R China

Recommended Citation:
Zhao, Yan Li,Tan, Shu Ping,Yang, Fu De,et al. Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings[J]. SCHIZOPHRENIA RESEARCH,2011,133(1-3):112-119.
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