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学科主题: 临床医学
题名:
Clinicopathological characteristics and outcomes of male lupus nephritis in China
作者: Wang, Y-F; Xu, Y-X; Tan, Y.; Yu, F.1; Zhao, M-H
关键词: Systemic lupus erythematosus (SLE) ; lupus nephritis ; male
刊名: LUPUS
发表日期: 2012-11-01
DOI: 10.1177/0961203312458467
卷: 21, 期:13, 页:1472-1481
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: SYSTEMIC-LUPUS ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; LABORATORY FEATURES ; INDUCTION TREATMENT ; RENAL-DISEASE ; ERYTHEMATOSUS ; GENDER ; SEX ; AUTOIMMUNITY
英文摘要:

Objective: The objective of this article is to assess clinicopathological characteristics and outcomes of patients with male lupus nephritis in a cohort of Chinese patients. Methods: Clinical, pathological and outcome data of lupus nephritis patients with different gender were retrospectively analyzed and compared. Results: Among 315 patients with renal biopsy-proven lupus nephritis, 45 were male and 270 were female. The average ages of disease onset of the male and female patients were comparable. The interval between presentation of lupus nephritis and diagnosis was significantly longer in the male group than in female group (p = 0.003). Clinical presentation was similar except that males had a significantly lower proportion of alopecia (p = 0.005). In laboratory data, male lupus nephritis patients had higher hemoglobin (p = 0.023) and higher serum creatinine (p < 0.001) than female patients. As for pathological classification and index, no significant difference was found between the two groups. The male patients presented with significantly lower ratios of complete remission and partial remission, and higher ratios of treatment failure and relapse than the female group. Regarding long-term survival and renal outcome, male patients had significantly worse prognosis than females (p = 0.005). Conclusions: The male lupus nephritis presented with later diagnosis, worse renal function, lower remission rate and higher relapse rate compared with female patients. The male patients had significantly higher mortality and poorer renal outcome. Lupus (2012) 21, 1472-1481.

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81100497 ; 7102150
项目资助者: Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000310160700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56000
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
2.Peking Univ, Div Renal, Dept Med, Hosp 1,Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Y-F,Xu, Y-X,Tan, Y.,et al. Clinicopathological characteristics and outcomes of male lupus nephritis in China[J]. LUPUS,2012,21(13):1472-1481.
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