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学科主题: 药学
题名:
Tissue distribution and pharmacokinetics evaluation of DOMC-FA micelles for intravenous delivery of PTX
作者: Wang, Feihu1,2; Zhang, Dianrui1; Zhang, Qiang3; Guo, Shengrong2; Zheng, Dandan1; Hao, Leilei1; Guo, Hejian1; Li, Caiyun1
关键词: Paclitaxel ; micelles ; DOMC-FA ; pharmacokinetics ; tissue distribution
刊名: JOURNAL OF DRUG TARGETING
发表日期: 2013-02-01
DOI: 10.3109/1061186X.2012.731067
卷: 21, 期:2, 页:137-145
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SOLID LIPID NANOPARTICLES ; INTRACELLULAR DELIVERY ; POLYMERIC MICELLES ; ANTICANCER DRUGS ; BLOCK-COPOLYMER ; PACLITAXEL ; BIODISTRIBUTION ; ACID
英文摘要:

A novel micelle formulation of paclitaxel (PTX) has been prepared for the purpose of prolonging the blood circulation time as well as modifying the biodistribution of PTX in comparison to a current PTX formulation, Taxol injection. This work was designed to investigate the preparation, in vitro release, in vivo pharmacokinetics, and tissue distribution of PTX-loaded DOMC-FA (deoxycholic acid- O-carboxymethylated chitosan-folic acid conjugate) micellar system. The micelles were prepared by self-assemble method using amphiphilic DOMC-FA polymer and a hydrophobic anticancer drug, PTX. The resultant PTX-loaded micelles had a mean size of approximately 152 nm with narrow size distribution and a spherical shape. The in vitro release profiles indicated that the release of PTX from the micelles exhibited a sustained release behavior. Pharmacokinetic study revealed that DOMC-FA/PTX micelles exhibited higher AUC values and a prolonged residence time of drug in the blood circulation than that of Taxol injection. The PTX-loaded micelles increased the uptake of PTX in the spleen, lung, and liver, but decreased uptake in the heart and kidney in the tissue distribution study. These results suggested that the DOMC-FA micelles can prolong blood circulation time and modify the tissue distribution of PTX, and could provide a useful alternative dosage form for intravenous administration of PTX.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China (973Program)
WOS记录号: WOS:000314475400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56005
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Feihu,Zhang, Dianrui,Zhang, Qiang,et al. Tissue distribution and pharmacokinetics evaluation of DOMC-FA micelles for intravenous delivery of PTX[J]. JOURNAL OF DRUG TARGETING,2013,21(2):137-145.
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