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Tissue distribution and pharmacokinetics evaluation of DOMC-FA micelles for intravenous delivery of PTX
Wang, Feihu1,2; Zhang, Dianrui1; Zhang, Qiang3; Guo, Shengrong2; Zheng, Dandan1; Hao, Leilei1; Guo, Hejian1; Li, Caiyun1
关键词Paclitaxel Micelles Domc-fa Pharmacokinetics Tissue Distribution
刊名JOURNAL OF DRUG TARGETING
2013-02-01
DOI10.3109/1061186X.2012.731067
21期:2页:137-145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SOLID LIPID NANOPARTICLES ; INTRACELLULAR DELIVERY ; POLYMERIC MICELLES ; ANTICANCER DRUGS ; BLOCK-COPOLYMER ; PACLITAXEL ; BIODISTRIBUTION ; ACID
英文摘要

A novel micelle formulation of paclitaxel (PTX) has been prepared for the purpose of prolonging the blood circulation time as well as modifying the biodistribution of PTX in comparison to a current PTX formulation, Taxol injection. This work was designed to investigate the preparation, in vitro release, in vivo pharmacokinetics, and tissue distribution of PTX-loaded DOMC-FA (deoxycholic acid- O-carboxymethylated chitosan-folic acid conjugate) micellar system. The micelles were prepared by self-assemble method using amphiphilic DOMC-FA polymer and a hydrophobic anticancer drug, PTX. The resultant PTX-loaded micelles had a mean size of approximately 152 nm with narrow size distribution and a spherical shape. The in vitro release profiles indicated that the release of PTX from the micelles exhibited a sustained release behavior. Pharmacokinetic study revealed that DOMC-FA/PTX micelles exhibited higher AUC values and a prolonged residence time of drug in the blood circulation than that of Taxol injection. The PTX-loaded micelles increased the uptake of PTX in the spleen, lung, and liver, but decreased uptake in the heart and kidney in the tissue distribution study. These results suggested that the DOMC-FA micelles can prolong blood circulation time and modify the tissue distribution of PTX, and could provide a useful alternative dosage form for intravenous administration of PTX.

语种英语
WOS记录号WOS:000314475400003
项目编号2009CB930300
资助机构National Basic Research Program of China (973Program)
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56005
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Shandong Univ, Dept Pharmaceut, Coll Pharm, Jinan 250012, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Feihu,Zhang, Dianrui,Zhang, Qiang,et al. Tissue distribution and pharmacokinetics evaluation of DOMC-FA micelles for intravenous delivery of PTX[J]. JOURNAL OF DRUG TARGETING,2013,21(2):137-145.
APA Wang, Feihu.,Zhang, Dianrui.,Zhang, Qiang.,Guo, Shengrong.,Zheng, Dandan.,...&Li, Caiyun.(2013).Tissue distribution and pharmacokinetics evaluation of DOMC-FA micelles for intravenous delivery of PTX.JOURNAL OF DRUG TARGETING,21(2),137-145.
MLA Wang, Feihu,et al."Tissue distribution and pharmacokinetics evaluation of DOMC-FA micelles for intravenous delivery of PTX".JOURNAL OF DRUG TARGETING 21.2(2013):137-145.
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