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学科主题: 临床医学
题名:
The roles of TGF-beta 1 gene transfer on collagen formation during Achilles tendon healing
作者: Hou, Yu; Mao, ZeBing; Wei, XueLei; Lin, Lin; Chen, LianXu; Wang, HaiJun; Fu, Xin; Zhang, JiYing; Yu, ChangLong
关键词: TGF-beta 1 ; Adenovirus ; BMSC ; Achilles tendon ; Collagen synthesis ; Cross-link formation ; Matrix remodeling
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-05-29
DOI: 10.1016/j.bbrc.2009.03.159
卷: 383, 期:2, 页:235-239
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: GROWTH-FACTOR-BETA ; TGF-BETA ; POLARIZATION MICROSCOPY ; PATELLAR TENDON ; LYSYL OXIDASE ; RAT MODEL ; IN-VITRO ; CELLS ; VIVO ; PROCOLLAGEN
英文摘要:

Collagen content and cross-linking are believed to be major determinants of tendon structural integrity and function. The current study aimed to investigate the effects of transforming growth factor (TGF)-beta 1 on the collagen content and cross-linking of Achilles tendons, and on the histological and biomechanical changes Occurring during Achilles tendon healing in rabbits. Bone marrow-derived mesenchymal stem cells (BMSCs) transfected with the TGF-beta 1 gene were surgically implanted into experimentally injured Achilles tendons. Collagen proteins were identified by immunohistochemical staining and fiber bundle accumulation was revealed by Sirius red staining. Achilles tendons treated with TGF-beta 1-transfected BMSCs showed higher concentrations of collagen I protein, more rapid matrix remodeling, and larger fiber bundles. Thus TGF-beta 1 can promote mechanical strength in healing Achilles tendons by regulating collagen synthesis, cross-link formation, and matrix remodeling. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000265867800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56006
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

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作者单位: Peking Univ, Inst Sports Med, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Hou, Yu,Mao, ZeBing,Wei, XueLei,et al. The roles of TGF-beta 1 gene transfer on collagen formation during Achilles tendon healing[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,383(2):235-239.
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