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学科主题临床医学
The roles of TGF-beta 1 gene transfer on collagen formation during Achilles tendon healing
Hou, Yu; Mao, ZeBing; Wei, XueLei; Lin, Lin; Chen, LianXu; Wang, HaiJun; Fu, Xin; Zhang, JiYing; Yu, ChangLong
关键词Tgf-beta 1 Adenovirus Bmsc Achilles Tendon Collagen Synthesis Cross-link Formation Matrix Remodeling
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-05-29
DOI10.1016/j.bbrc.2009.03.159
383期:2页:235-239
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]GROWTH-FACTOR-BETA ; TGF-BETA ; POLARIZATION MICROSCOPY ; PATELLAR TENDON ; LYSYL OXIDASE ; RAT MODEL ; IN-VITRO ; CELLS ; VIVO ; PROCOLLAGEN
英文摘要

Collagen content and cross-linking are believed to be major determinants of tendon structural integrity and function. The current study aimed to investigate the effects of transforming growth factor (TGF)-beta 1 on the collagen content and cross-linking of Achilles tendons, and on the histological and biomechanical changes Occurring during Achilles tendon healing in rabbits. Bone marrow-derived mesenchymal stem cells (BMSCs) transfected with the TGF-beta 1 gene were surgically implanted into experimentally injured Achilles tendons. Collagen proteins were identified by immunohistochemical staining and fiber bundle accumulation was revealed by Sirius red staining. Achilles tendons treated with TGF-beta 1-transfected BMSCs showed higher concentrations of collagen I protein, more rapid matrix remodeling, and larger fiber bundles. Thus TGF-beta 1 can promote mechanical strength in healing Achilles tendons by regulating collagen synthesis, cross-link formation, and matrix remodeling. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000265867800017
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56006
专题北京大学第三临床医学院_运动医学研究所
作者单位Peking Univ, Inst Sports Med, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hou, Yu,Mao, ZeBing,Wei, XueLei,et al. The roles of TGF-beta 1 gene transfer on collagen formation during Achilles tendon healing[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,383(2):235-239.
APA Hou, Yu.,Mao, ZeBing.,Wei, XueLei.,Lin, Lin.,Chen, LianXu.,...&Yu, ChangLong.(2009).The roles of TGF-beta 1 gene transfer on collagen formation during Achilles tendon healing.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,383(2),235-239.
MLA Hou, Yu,et al."The roles of TGF-beta 1 gene transfer on collagen formation during Achilles tendon healing".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 383.2(2009):235-239.
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