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学科主题: 口腔医学
题名:
Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries
作者: Zhou, Qiong; Qin, Xiurong; Qin, Man; Ge, Lihong
刊名: INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
发表日期: 2011-11-01
DOI: 10.1111/j.1365-263X.2011.01145.x
卷: 21, 期:6, 页:422-431
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Pediatrics
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Pediatrics
关键词[WOS]: POLYMERASE-CHAIN-REACTION ; ORAL COLONIZATION ; DENTAL-CARIES ; TRANSMISSION ; PREVALENCE ; STRAINS ; HUMANS ; SALIVA ; PLAQUE ; ROOT
英文摘要:

Background. The genotypic diversity of both Streptococcus mutans and Streptococcus sobrinus in children with different caries experience remains unclear.

Aim. To investigate the genotypic diversity of S. mutans and S. sobrinus in children with severe early childhood caries (SECC) and in caries-free (CF) children.

Methods. Stimulated saliva of 87 SECC and 91 CF children aged 3-4 years was collected and submitted to cultivation, and MS colonies were enumerated. The genomic fingerprint analysis of S. mutans and S. sobrinus was carried out using AP-PCR.

Results. One to five genotypes of S. mutans were colonized in an oral cavity of SECC and CF children; 85.5% SECC children and 57.9% CF children harboured more than one genotype of S. mutans. One to three genotypes of S. sobrinus were detected from each SECC child; 31.25% SECC children harboured more than one genotype of S. sobrinus. And one genotype was colonized in each CF child. S. mutans isolates from different individuals displayed distinctive DNA fingerprints.

Conclusions. DNA fingerprints of S. mutans and S. sobrinus isolates from 3- to 4-year-old children displayed genetic polymorphism, and S. mutans has greater genetic diversity than S. sobrinus. SECC children harboured more genotypes of S. mutans and S. sobrinus than CF children.

语种: 英语
所属项目编号: 2002-3035
项目资助者: Fund of Beijing Medical Research and Development
WOS记录号: WOS:000296060800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56009
Appears in Collections:北京大学口腔医学院_儿童口腔科_期刊论文

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作者单位: Peking Univ, Sch Stomatol, Dept Pediat Dent, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Qiong,Qin, Xiurong,Qin, Man,et al. Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries[J]. INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,2011,21(6):422-431.
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