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学科主题口腔医学
Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries
Zhou, Qiong; Qin, Xiurong; Qin, Man; Ge, Lihong
刊名INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
2011-11-01
DOI10.1111/j.1365-263X.2011.01145.x
21期:6页:422-431
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Pediatrics
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Pediatrics
关键词[WOS]POLYMERASE-CHAIN-REACTION ; ORAL COLONIZATION ; DENTAL-CARIES ; TRANSMISSION ; PREVALENCE ; STRAINS ; HUMANS ; SALIVA ; PLAQUE ; ROOT
英文摘要

Background. The genotypic diversity of both Streptococcus mutans and Streptococcus sobrinus in children with different caries experience remains unclear.

Aim. To investigate the genotypic diversity of S. mutans and S. sobrinus in children with severe early childhood caries (SECC) and in caries-free (CF) children.

Methods. Stimulated saliva of 87 SECC and 91 CF children aged 3-4 years was collected and submitted to cultivation, and MS colonies were enumerated. The genomic fingerprint analysis of S. mutans and S. sobrinus was carried out using AP-PCR.

Results. One to five genotypes of S. mutans were colonized in an oral cavity of SECC and CF children; 85.5% SECC children and 57.9% CF children harboured more than one genotype of S. mutans. One to three genotypes of S. sobrinus were detected from each SECC child; 31.25% SECC children harboured more than one genotype of S. sobrinus. And one genotype was colonized in each CF child. S. mutans isolates from different individuals displayed distinctive DNA fingerprints.

Conclusions. DNA fingerprints of S. mutans and S. sobrinus isolates from 3- to 4-year-old children displayed genetic polymorphism, and S. mutans has greater genetic diversity than S. sobrinus. SECC children harboured more genotypes of S. mutans and S. sobrinus than CF children.

语种英语
WOS记录号WOS:000296060800004
项目编号2002-3035
资助机构Fund of Beijing Medical Research and Development
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56009
专题北京大学口腔医学院_儿童口腔科
作者单位Peking Univ, Sch Stomatol, Dept Pediat Dent, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Qiong,Qin, Xiurong,Qin, Man,et al. Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries[J]. INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,2011,21(6):422-431.
APA Zhou, Qiong,Qin, Xiurong,Qin, Man,&Ge, Lihong.(2011).Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries.INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY,21(6),422-431.
MLA Zhou, Qiong,et al."Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries".INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY 21.6(2011):422-431.
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