|Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer|
|Zhang, Bao-yan1; Yuan, Jing2; Cui, Zhen-shuang3; Li, Zhong-wu4; Li, Xiang-hong4; Lu, You-yong5|
|关键词||Gastric Cancer Prognosis Tnm Metastatic Lymph Node Ratio Pn Category|
|刊名||AMERICAN JOURNAL OF SURGERY|
|WOS标题词||Science & Technology|
|关键词[WOS]||N-RATIO ; TNM CLASSIFICATION ; CARCINOMA ; NUMBER ; IMPACT ; EPIDEMIOLOGY ; RESECTION ; SURVIVAL|
BACKGROUND: The aim of this study was to investigate the prognostic value of metastatic lymph node (LN) ratio (LNR) compared with pathologic node (pN) category.
METHODS: Three hundred ninety-nine patients with gastric cancer with R0 resection were reviewed. LNR, pN, and the number of retrieved LNs were evaluated in node-positive groups with >= 15 or <15 LNs resected and a node-negative group, respectively, by univariate and multivariate analyses. Associations of pN and LNR with the number of retrieved LNs were determined using Spearman′s rank correlation test.
RESULTS: LNR and pN were correlated with overall survival. For the node-positive group with >= 15 LNs retrieved, pN and LNR were independent prognostic factors, with the hazard ratio higher for LNR; neither was correlated with the number of retrieved LNs. For the group with <15 LNs retrieved, LNR but not pN was an independent prognostic factor, with LNR uncorrelated with the number of LNs retrieved. For the node-negative group, the number of LNs retrieved retained an independent prognostic factor.
CONCLUSIONS: LNR is an independent prognostic factor in node-positive patients with gastric cancer with R0 resection, and it is uninfluenced by the number of LNs retrieved. It may be superior to pN. (C) 2014 Elsevier Inc. All rights reserved.
|项目编号||2006AA02A402 ; 2012AA02A504|
|资助机构||National Bio-Tech 863|
|作者单位||1.Chinese PLA, Hosp 117, Dept Pathol, Hangzhou, Zhejiang, Peoples R China|
2.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Beijing Mil Area, Cadre Ward Internal Med, Beijing, Peoples R China
4.Peking Univ, Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
|Zhang, Bao-yan,Yuan, Jing,Cui, Zhen-shuang,et al. Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer[J]. AMERICAN JOURNAL OF SURGERY,2014,207(4):555-565.|
|APA||Zhang, Bao-yan,Yuan, Jing,Cui, Zhen-shuang,Li, Zhong-wu,Li, Xiang-hong,&Lu, You-yong.(2014).Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer.AMERICAN JOURNAL OF SURGERY,207(4),555-565.|
|MLA||Zhang, Bao-yan,et al."Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer".AMERICAN JOURNAL OF SURGERY 207.4(2014):555-565.|