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Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer
Zhang, Bao-yan1; Yuan, Jing2; Cui, Zhen-shuang3; Li, Zhong-wu4; Li, Xiang-hong4; Lu, You-yong5
关键词Gastric Cancer Prognosis Tnm Metastatic Lymph Node Ratio Pn Category
刊名AMERICAN JOURNAL OF SURGERY
2014-04-01
DOI10.1016/j.amjsurg.2013.05.004
207期:4页:555-565
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]N-RATIO ; TNM CLASSIFICATION ; CARCINOMA ; NUMBER ; IMPACT ; EPIDEMIOLOGY ; RESECTION ; SURVIVAL
英文摘要

BACKGROUND: The aim of this study was to investigate the prognostic value of metastatic lymph node (LN) ratio (LNR) compared with pathologic node (pN) category.

METHODS: Three hundred ninety-nine patients with gastric cancer with R0 resection were reviewed. LNR, pN, and the number of retrieved LNs were evaluated in node-positive groups with >= 15 or <15 LNs resected and a node-negative group, respectively, by univariate and multivariate analyses. Associations of pN and LNR with the number of retrieved LNs were determined using Spearman′s rank correlation test.

RESULTS: LNR and pN were correlated with overall survival. For the node-positive group with >= 15 LNs retrieved, pN and LNR were independent prognostic factors, with the hazard ratio higher for LNR; neither was correlated with the number of retrieved LNs. For the group with <15 LNs retrieved, LNR but not pN was an independent prognostic factor, with LNR uncorrelated with the number of LNs retrieved. For the node-negative group, the number of LNs retrieved retained an independent prognostic factor.

CONCLUSIONS: LNR is an independent prognostic factor in node-positive patients with gastric cancer with R0 resection, and it is uninfluenced by the number of LNs retrieved. It may be superior to pN. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000333416100016
项目编号2006AA02A402 ; 2012AA02A504
资助机构National Bio-Tech 863
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56010
专题北京大学临床肿瘤学院_病理科
作者单位1.Chinese PLA, Hosp 117, Dept Pathol, Hangzhou, Zhejiang, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Beijing Mil Area, Cadre Ward Internal Med, Beijing, Peoples R China
4.Peking Univ, Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Bao-yan,Yuan, Jing,Cui, Zhen-shuang,et al. Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer[J]. AMERICAN JOURNAL OF SURGERY,2014,207(4):555-565.
APA Zhang, Bao-yan,Yuan, Jing,Cui, Zhen-shuang,Li, Zhong-wu,Li, Xiang-hong,&Lu, You-yong.(2014).Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer.AMERICAN JOURNAL OF SURGERY,207(4),555-565.
MLA Zhang, Bao-yan,et al."Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer".AMERICAN JOURNAL OF SURGERY 207.4(2014):555-565.
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