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学科主题: 临床医学
题名:
Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer
作者: Zhang, Bao-yan1; Yuan, Jing2; Cui, Zhen-shuang3; Li, Zhong-wu4; Li, Xiang-hong4; Lu, You-yong5
关键词: Gastric cancer ; Prognosis ; TNM ; Metastatic lymph node ratio ; pN category
刊名: AMERICAN JOURNAL OF SURGERY
发表日期: 2014-04-01
DOI: 10.1016/j.amjsurg.2013.05.004
卷: 207, 期:4, 页:555-565
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: N-RATIO ; TNM CLASSIFICATION ; CARCINOMA ; NUMBER ; IMPACT ; EPIDEMIOLOGY ; RESECTION ; SURVIVAL
英文摘要:

BACKGROUND: The aim of this study was to investigate the prognostic value of metastatic lymph node (LN) ratio (LNR) compared with pathologic node (pN) category.

METHODS: Three hundred ninety-nine patients with gastric cancer with R0 resection were reviewed. LNR, pN, and the number of retrieved LNs were evaluated in node-positive groups with >= 15 or <15 LNs resected and a node-negative group, respectively, by univariate and multivariate analyses. Associations of pN and LNR with the number of retrieved LNs were determined using Spearman′s rank correlation test.

RESULTS: LNR and pN were correlated with overall survival. For the node-positive group with >= 15 LNs retrieved, pN and LNR were independent prognostic factors, with the hazard ratio higher for LNR; neither was correlated with the number of retrieved LNs. For the group with <15 LNs retrieved, LNR but not pN was an independent prognostic factor, with LNR uncorrelated with the number of LNs retrieved. For the node-negative group, the number of LNs retrieved retained an independent prognostic factor.

CONCLUSIONS: LNR is an independent prognostic factor in node-positive patients with gastric cancer with R0 resection, and it is uninfluenced by the number of LNs retrieved. It may be superior to pN. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A402 ; 2012AA02A504
项目资助者: National Bio-Tech 863
WOS记录号: WOS:000333416100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56010
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Chinese PLA, Hosp 117, Dept Pathol, Hangzhou, Zhejiang, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Beijing Mil Area, Cadre Ward Internal Med, Beijing, Peoples R China
4.Peking Univ, Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Zhang, Bao-yan,Yuan, Jing,Cui, Zhen-shuang,et al. Evaluation of the prognostic value of the metastatic lymph node ratio for gastric cancer[J]. AMERICAN JOURNAL OF SURGERY,2014,207(4):555-565.
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